Scrobiculosides A and B from the deep-sea sponge Pachastrella scrobiculosa

• Published in: Journal of natural medicines Vol. 73; no. 4; pp. 814 - 819
• Main Authors: Jomori, Takahiro, Shiroyama, Shuji, Ise, Yuji, Kohtsuka, Hisanori, Matsuda, Kenichi, Kuranaga, Takefumi, Wakimoto, Toshiyuki
• Format: Journal Article
• Language: English
• Published: Singapore Springer Singapore 01.09.2019; Springer Nature B.V
• Subjects: Aglycones; Animals; Biomedical and Life Sciences; Biomedicine; Cell Line, Tumor; Complementary & Alternative Medicine; Cytotoxicity; HL-60 Cells; Humans; Japan; Medicinal Chemistry; Molecular Structure; Natural products; Pachastrella; Pharmacology/Toxicology; Pharmacy; Phytochemicals; Plant Sciences; Porifera - metabolism; Saponins; Saponins - chemistry; Saponins - isolation & purification; Saponins - pharmacology; Steroids - chemistry; Steroids - isolation & purification; Steroids - pharmacology; Sugar; Japan; Deep-sea sponge; Cytotoxicity; Scrobiculoside; Pachastrella scrobiculosa
• ISSN: 1340-3443; 1861-0293
• DOI: 10.1007/s11418-019-01315-6

Two new steroidal saponins, scrobiculosides A and B, were isolated from the deep-sea sponge Pachastrella scrobiculosa , collected at a depth of 200 m off Miura Peninsula, Japan. The aglycones of scrobiculosides A and B feature a vinylic cyclopropane and a ∆ 24,25 exomethylene on the side chains, respectively. Both saponins have a common sugar moiety composed of β- d -galactopyranosyl-(1 → 2)-6-acetyl-β- d -glucopyranoside, with the exception of an acetyl group on C6″ in scrobiculoside A. Scrobiculoside A exhibited cytotoxicity against HL-60 and P388 cells, with IC 50 values of 52 and 61 μM, respectively.