The Effect of Amantadine on Corneal Endothelium in Subjects with Parkinson's Disease

• Published in: Ophthalmology (Rochester, Minn.) Vol. 117; no. 6; pp. 1214 - 1219
• Main Authors: Chang, Ki Cheol, MD, Jeong, Jin Ho, MD, Kim, Mee Kum, MD, PhD, Wee, Won Ryang, MD, PhD, Lee, Jin Hak, MD, PhD, Jeon, Beom Seok, MD, PhD
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.06.2010; Elsevier
• Subjects: Adult; Aged; Amantadine - adverse effects; Antiparkinson Agents - adverse effects; Biological and medical sciences; Cell Count; Corneal Diseases - chemically induced; Corneal Diseases - pathology; Cross-Sectional Studies; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Dose-Response Relationship, Drug; Endothelium, Corneal - drug effects; Endothelium, Corneal - pathology; Female; Humans; Male; Medical sciences; Middle Aged; Miscellaneous; Nervous system (semeiology, syndromes); Nervous system as a whole; Neurology; Ophthalmology; Parkinson Disease - drug therapy; Human; Agonist; Nervous system diseases; Amantadine; Cornea; Dopamine receptor; Parkinson disease; Glutamate receptor; Antiparkinson agent; Cerebral disorder; Endothelium; Amantadine derivatives; Central nervous system disease; Dopamine agonist; Antiviral; Degenerative disease; Antagonist; Ophthalmology; NMDA receptor; Extrapyramidal syndrome
• ISSN: 0161-6420; 1549-4713
• DOI: 10.1016/j.ophtha.2009.10.039

Objective To evaluate the effect of amantadine on corneal endothelial cells in subjects with Parkinson's disease. Design Cross-sectional study. Participants A total of 169 subjects (169 eyes) taking amantadine orally for Parkinson's disease and the same number of age- and gender-matched controls. Methods Endothelial indices were compared between the amantadine-treated and age-matched control groups. The amantadine-treated group was divided into 3 subgroups according to the cumulative dose and duration of treatment. Endothelial changes were compared between the amantadine group and the normal control group, and among subgroups. Main Outcome Measures Slit-lamp biomicroscopy, central corneal thickness (CCT), endothelial cell density (ECD), coefficient of variation, and hexagonality. Results The amantadine group had significantly lower ECD (mean ± standard error; 2662.47±29.06 vs. 2784.72±25.89, P = 0.002), lower hexagonality (56.94±1.07 vs. 60.97±0.87, P = 0.004), and greater coefficient of variation (35.59±0.57 vs. 32.66±0.52, P = 0.000) compared with the age-matched control group. Longer duration and higher cumulative dose amantadine therapy led to a greater reduction in ECD ( P <0.05) compared with the normal age-matched control group. Conclusions Amantadine is more likely to have an effect on corneal endothelial cells in a dose-dependent manner when used long-term. Financial Disclosure(s) The author(s) have no proprietary or commercial interest in any materials discussed in this article.