Cardiac gene regulatory networks in Drosophila

The Drosophila system has proven a powerful tool to help unlock the regulatory processes that occur during specification and differentiation of the embryonic heart. In this review, we focus upon a temporal analysis of the molecular events that result in heart formation in Drosophila, with a particul...

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Bibliographic Details
Published inBiochimica et biophysica acta Vol. 1789; no. 4; pp. 343 - 353
Main Authors Bryantsev, Anton L., Cripps, Richard M.
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.04.2009
Subjects
Animals
Cardiac specification
Drosophila
Drosophila - embryology
Drosophila - genetics
Embryo, Nonmammalian - cytology
Embryo, Nonmammalian - metabolism
Gene network
Gene Regulatory Networks
Heart
Heart - physiology
Heart development
MEF2
Systems approach
Tinman
Transcription factor
Heart
MEF2
Systems approach
Tinman
Drosophila
Heart development
Gene network
Cardiac specification
Transcription factor
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Summary:The Drosophila system has proven a powerful tool to help unlock the regulatory processes that occur during specification and differentiation of the embryonic heart. In this review, we focus upon a temporal analysis of the molecular events that result in heart formation in Drosophila, with a particular emphasis upon how genomic and other cutting-edge approaches are being brought to bear upon the subject. We anticipate that systems-level approaches will contribute greatly to our comprehension of heart development and disease in the animal kingdom.
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ISSN:1874-9399
0006-3002
1876-4320
DOI:10.1016/j.bbagrm.2008.09.002