Synthesis, spectral and solid state characterization of a new bioactive hydrazine bridged cyclic diphosphonium compound

The facile preparation of a racemic hydrazine bridged diphosphonium compound possessing a ring system analogous to bicyclo[3.3.2]decane is reported. Although the reaction yield is low, the structure of the compound, which possesses an eight-membered ring, two phosphonium cationic centers, a biimino...

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Published inMolecules (Basel, Switzerland) Vol. 17; no. 3; pp. 2567 - 2578
Main Authors Milenković, Milica, Warżajtis, Beata, Rychlewska, Urszula, Radanović, Dušanka, Anđelković, Katarina, Božić, Tatjana, Vujčić, Miroslava, Sladić, Dušan
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 02.03.2012
MDPI
Subjects
Acids
Animals
Artemia - drug effects
Biological activity
Bridged Bicyclo Compounds - chemical synthesis
Bridged Bicyclo Compounds - chemistry
Bridged Bicyclo Compounds - pharmacology
brine shrimp test
Crystallography, X-Ray
Crystals
Cytotoxins - chemical synthesis
Cytotoxins - chemistry
Cytotoxins - pharmacology
DNA Cleavage
DNA, Circular - chemistry
hydrazine bridged diphosphonium compound
Hydrogen
Lethal Dose 50
Ligands
Magnetic Resonance Spectroscopy
Models, Molecular
Molecular Conformation
Molecular Structure
Plasmids - chemistry
Symmetry
X-ray
Serbia
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Summary:The facile preparation of a racemic hydrazine bridged diphosphonium compound possessing a ring system analogous to bicyclo[3.3.2]decane is reported. Although the reaction yield is low, the structure of the compound, which possesses an eight-membered ring, two phosphonium cationic centers, a biimino bridge, molecular chirality and two fused aromatic rings locked into roughly perpendicular planes is unusual. The compound displays substantial biological activity in the brine shrimp test and cleaves plasmid DNA.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules17032567