Specific exercise patterns generate an epigenetic molecular memory window that drives long-term memory formation and identifies ACVR1C as a bidirectional regulator of memory in mice

• Published in: Nature communications Vol. 15; no. 1; p. 3836
• Main Authors: Keiser, Ashley A., Dong, Tri N., Kramár, Enikö A., Butler, Christopher W., Chen, Siwei, Matheos, Dina P., Rounds, Jacob S., Rodriguez, Alyssa, Beardwood, Joy H., Augustynski, Agatha S., Al-Shammari, Ameer, Alaghband, Yasaman, Alizo Vera, Vanessa, Berchtold, Nicole C., Shanur, Sharmin, Baldi, Pierre, Cotman, Carl W., Wood, Marcelo A.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 07.05.2024; Nature Publishing Group; Nature Portfolio
• Subjects: 38/1; 38/15; 38/44; 38/77; 38/88; 38/90; 38/91; 45/15; 45/77; 45/91; 49/88; 631/378/1595; 631/378/340; 64/60; 82/1; 82/51; 96/63; Activin Receptors, Type I - genetics; Activin Receptors, Type I - metabolism; Aging; Aging - genetics; Aging - physiology; Animals; Cognition; Cognitive ability; Epigenesis, Genetic; Epigenetics; Female; Gene expression; Genes; Hippocampus - metabolism; Humanities and Social Sciences; Humans; Life span; Long term memory; Male; Memory; Memory, Long-Term - physiology; Mice; Mice, Inbred C57BL; multidisciplinary; Neuronal Plasticity - genetics; Overexpression; Physical Conditioning, Animal - physiology; Plasticity; Promoter Regions, Genetic; Science; Science (multidisciplinary); Synaptic plasticity; Training
• ISSN: 2041-1723; 2041-1723
• DOI: 10.1038/s41467-024-47996-w

Exercise has beneficial effects on cognition throughout the lifespan. Here, we demonstrate that specific exercise patterns transform insufficient, subthreshold training into long-term memory in mice. Our findings reveal a potential molecular memory window such that subthreshold training within this window enables long-term memory formation. We performed RNA-seq on dorsal hippocampus and identify genes whose expression correlate with conditions in which exercise enables long-term memory formation. Among these genes we found Acvr1c , a member of the TGF ß family. We find that exercise, in any amount, alleviates epigenetic repression at the Acvr1c promoter during consolidation. Additionally, we find that ACVR1C can bidirectionally regulate synaptic plasticity and long-term memory in mice. Furthermore, Acvr1c expression is impaired in the aging human and mouse brain, as well as in the 5xFAD mouse model, and over-expression of Acvr1c enables learning and facilitates plasticity in mice. These data suggest that promoting ACVR1C may protect against cognitive impairment. Exercise has beneficial effects on cognition. Here, authors utilize an exercise model to show ACVR1C to be an essential bidirectional regulator of memory and synaptic plasticity in adult, aging and 5xFAD mice beyond the context of exercise.