Effect of Antibodies to Glutamate on Retention of Conditioned Passive Avoidance Response in Rats with Ischemic Injury of the Prefrontal Cortex

• Published in: Bulletin of experimental biology and medicine Vol. 149; no. 3; pp. 289 - 292
• Main Authors: Romanova, G. A, Shakova, F. M, Gorbatov, V. Yu, Kvashennikova, Yu. N, Davydova, T. V
• Format: Journal Article
• Language: English
• Published: Boston Boston : Springer US 01.09.2010; Springer US; Springer; Springer Nature B.V
• Subjects: Amino acids; Animals; Antibodies; Antibodies - administration & dosage; Antibodies - pharmacology; antibodies to glutamate; Avoidance Learning - drug effects; Avoidance Learning - physiology; Biomedical and Life Sciences; Biomedicine; Brain Ischemia - drug therapy; Cell Biology; Enzyme-Linked Immunosorbent Assay; Glutamate; Glutamic Acid - immunology; Internal Medicine; Ischemia; Laboratory Medicine; learning; Male; memory; Pathology; Photochemistry - methods; photothrombosis; prefrontal cortex; Prefrontal Cortex - physiopathology; Rats; Rose Bengal; Statistics, Nonparametric; Stroke (Disease); Viral antibodies; learning; antibodies to glutamate; memory; prefrontal cortex; photothrombosis
• ISSN: 0007-4888; 1573-8221
• DOI: 10.1007/s10517-010-0929-9

Experiments were performed on rats with bilateral photothrombosis of vessels in the prefrontal cortex. Intranasal administration of antibodies to glutamate (1 h after ischemia of the brain cortex) improved retention of conditioned passive avoidance response, which was elicited before ischemic damage. The content of antibodies to glutamate in the serum of rats increased significantly on day 8 after bilateral photochemical thrombosis of vessels in the prefrontal cortex compared to that in the control.