Impact of pore characteristics of silica materials on loading capacity and release behavior of ibuprofen

• Published in: Materials Science & Engineering C Vol. 59; pp. 43 - 52
• Main Authors: Numpilai, Thanapha, Muenmee, Suthaporn, Witoon, Thongthai
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.02.2016
• Subjects: Bearing strength; Bimodal porous silica; Delayed-Action Preparations - chemistry; Delayed-Action Preparations - pharmacokinetics; Dissolution; Dissolution efficiency; Fourier transforms; Ibuprofen; Ibuprofen - chemistry; Ibuprofen - pharmacokinetics; Infrared spectroscopy; Physical stability; Porosity; Porous materials; Scanning electron microscopy; Silicon dioxide; Silicon Dioxide - chemistry; Solid dispersion; Bimodal porous silica; Solid dispersion; Dissolution efficiency; Ibuprofen; Physical stability
• ISSN: 0928-4931; 1873-0191
• DOI: 10.1016/j.msec.2015.09.095

Impact of pore characteristics of porous silica supports on loading capacity and release behavior of ibuprofen was investigated. The porous silica materials and ibuprofen-loaded porous silica materials were thoroughly characterized by N2-sorption, thermal gravimetric and derivative weight analyses (TG-DTW), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), scanning electron microscope (SEM), transmission electron microscope (TEM) to determine the physical properties of materials, amount of ibuprofen adsorbed and position of ibuprofen. The detailed characterization reveals that the ibuprofen molecules adsorbed inside the mesopores. Increasing the mesopore size from 5nm to 10nm increased the ibuprofen loading from 0.74 to 0.85mmol/g, respectively. Incorporation of macropore into the structure of porous silica materials enhanced the ibuprofen loading capacity of 11.8–20.3%. The ibuprofen-loaded bimodal meso-macroporous silica materials exhibited the highest dissolution of 92wt.% within an hour. The ibuprofen particles deposited on the external surface of the porous silica materials showed a lower dissolution rate than the ibuprofen adsorbed inside the mesopores due to the formation of ibuprofen crystalline. [Display omitted] •Impacts of pore characteristics of supports on adsorption and release of ibuprofen•Increasing mesopore size increased the ibuprofen loading and dissolution rate.•Macropores reduced the diffusion pathway of ibuprofen and dissolution medium.