Catenane organocatalyst breaks the linear scaling limitation through conformational selection

• Published in: Communications chemistry Vol. 7; no. 1; p. 9
• Main Author: Wang, Chenyu
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 08.01.2024; Nature Publishing Group; Nature Portfolio
• Subjects: 639/638/403; 639/638/541/964; 639/638/77/888; Catalysis; Chemistry; Chemistry and Materials Science; Chemistry/Food Science; Research Highlight

Conformational dynamics are integral to enzyme catalysis, yet they are barely explored when designing synthetic catalysts. Now, a catenane-based organocatalyst, which dynamically switches between two conformations, speeds up the catalysis of carbodiimide hydration through spontaneous conformational...