Catenane organocatalyst breaks the linear scaling limitation through conformational selection

Conformational dynamics are integral to enzyme catalysis, yet they are barely explored when designing synthetic catalysts. Now, a catenane-based organocatalyst, which dynamically switches between two conformations, speeds up the catalysis of carbodiimide hydration through spontaneous conformational...

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Bibliographic Details
Published inCommunications chemistry Vol. 7; no. 1; p. 9
Main Author Wang, Chenyu
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 08.01.2024
Nature Publishing Group
Nature Portfolio
Subjects
639/638/403
639/638/541/964
639/638/77/888
Catalysis
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Research Highlight
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Summary:Conformational dynamics are integral to enzyme catalysis, yet they are barely explored when designing synthetic catalysts. Now, a catenane-based organocatalyst, which dynamically switches between two conformations, speeds up the catalysis of carbodiimide hydration through spontaneous conformational adaptation for different reaction steps.
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ISSN:2399-3669
2399-3669
DOI:10.1038/s42004-023-01088-w