Investigation of the effectiveness of a classification method based on improved DAE feature extraction for hepatitis C prediction

• Published in: Scientific reports Vol. 14; no. 1; p. 9143
• Main Authors: Zhang, Lin, Wang, Jixin, Chang, Rui, Wang, Weigang
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 21.04.2024; Nature Publishing Group; Nature Portfolio
• Subjects: 639/705; 692/699/1541; Accuracy; Algorithms; Autoencoder; Classification; Deep learning; Denoising autoencoder; Disease; Disease detection; Hepatitis; Hepatitis C; Humanities and Social Sciences; multidisciplinary; Neural networks; Predictions; Public health; Science; Science (multidisciplinary); Warning systems; Hepatitis C; Autoencoder; Denoising autoencoder
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-024-59785-y

Hepatitis C, a particularly dangerous form of viral hepatitis caused by hepatitis C virus (HCV) infection, is a major socio-economic and public health problem. Due to the rapid development of deep learning, it has become a common practice to apply deep learning to the healthcare industry to improve the effectiveness and accuracy of disease identification. In order to improve the effectiveness and accuracy of hepatitis C detection, this study proposes an improved denoising autoencoder (IDAE) and applies it to hepatitis C disease detection. Conventional denoising autoencoder introduces random noise at the input layer of the encoder. However, due to the presence of these features, encoders that directly add random noise may mask certain intrinsic properties of the data, making it challenging to learn deeper features. In this study, the problem of data information loss in traditional denoising autoencoding is addressed by incorporating the concept of residual neural networks into an enhanced denoising autoencoder. In our experimental study, we applied this enhanced denoising autoencoder to the open-source Hepatitis C dataset and the results showed significant results in feature extraction. While existing baseline machine learning methods have less than 90% accuracy and integrated algorithms and traditional autoencoders have only 95% correctness, the improved IDAE achieves 99% accuracy in the downstream hepatitis C classification task, which is a 9% improvement over a single algorithm, and a nearly 4% improvement over integrated algorithms and other autoencoders. The above results demonstrate that IDAE can effectively capture key disease features and improve the accuracy of disease prediction in hepatitis C data. This indicates that IDAE has the potential to be widely used in the detection and management of hepatitis C and similar diseases, especially in the development of early warning systems, progression prediction and personalised treatment strategies.