Association between Hypertriglyceridemia and Lacunar Infarction in Type 2 Diabetes Mellitus

• Published in: Journal of stroke and cerebrovascular diseases Vol. 24; no. 8; pp. 1873 - 1878
• Main Authors: Shin, Dong-Won, MD, Lee, Kyung Bok, MD, PhD, Seo, Jae-Young, MD, Kim, Ji-Sun, MD, Roh, Hakjae, MD, Ahn, Moo-Young, MD, Lee, Ji-Sung, PhD
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.08.2015
• Subjects: acute ischemic stroke; Aged; Aged, 80 and over; Analysis of Variance; Cardiovascular; Cholesterol - blood; diabetes mellitus; Diabetes Mellitus, Type 2 - complications; Female; Humans; Hypertriglyceridemia; Hypertriglyceridemia - etiology; lacunar infarcts; Lipids - blood; Male; Middle Aged; Neurology; Retrospective Studies; Risk Factors; Stroke - complications; Stroke, Lacunar - etiology; diabetes mellitus; Hypertriglyceridemia; acute ischemic stroke; lacunar infarcts
• ISSN: 1052-3057; 1532-8511
• DOI: 10.1016/j.jstrokecerebrovasdis.2015.04.030

Background Although recent studies have shown that the elevation of serum triglyceride (TG) is related to the increased incidence of ischemic stroke, the relationship between hypertriglyceridemia and subtypes of ischemic stroke is largely unknown. This study attempted to evaluate whether hypertriglyceridemia is associated with lacunar stroke in diabetes mellitus (DM). Methods A total of 2141 consecutive patients with acute ischemic stroke were enrolled from March 2005 to April 2014, excluding the subjects with undetermined/other determined etiology or no lipid data. We compared the lipid profiles among stroke subtypes. The estimated serum TG levels and the interaction between DM and stroke subtypes were determined by analysis of covariance (ANCOVA) and Tukey's multiple comparison. Results In ANCOVA test, the difference of estimated TG between DM and non-DM patients was largest in small-vessel occlusion (SVO; 159.7 [95% confidence interval {CI}, 143.2-176.2] versus 122.4 [95% CI, 106.1-138.7]), and a significant interaction was observed between DM and stroke subtypes for TG levels ( P  = .013) but not for total cholesterol ( P  = .363), low-density lipoprotein cholesterol ( P  = .171), or high-density lipoprotein cholesterol ( P  = .231). By Tukey's multiple comparison, SVO was consistently associated with DM for serum TG levels ( P  < .001). Conclusions In acute ischemic stroke with DM, serum TG level was significantly associated with lacunar infarction adjusting for other lipid profiles and vascular risk factors. Further studies are warranted to reveal the pathophysiologic implication of hypertriglyceridemia for lacunar infarction in type 2 DM.