Lack of furosemide responsiveness predict severe acute kidney injury after liver transplantation

• Published in: Scientific reports Vol. 13; no. 1; p. 4978
• Main Authors: Cai, Li, Shu, Liu, Yujun, Zhao, Ke, Cheng, Qiang, Wang
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 27.03.2023; Nature Publishing Group; Nature Portfolio
• Subjects: 692/53; 692/699/1503; 692/699/1585; Acute Kidney Injury - diagnosis; Acute Kidney Injury - etiology; Acute Kidney Injury - therapy; Biomarkers; Furosemide; Furosemide - therapeutic use; Humanities and Social Sciences; Humans; Kidney transplantation; Kidneys; Liver transplantation; Liver Transplantation - adverse effects; Liver transplants; multidisciplinary; Retrospective Studies; ROC Curve; Science; Science (multidisciplinary); Urine
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-023-31757-8

Acute kidney injury (AKI) remains to be a common but severe complication after liver transplantation (LT). However, there are still few clinically validated biomarkers. A total of 214 patients who underwent routine furosemide (1–2 mg/kg) after LT were retrospectively included. The urine output during the first 6 h was recorded to evaluate the predictive value of AKI stage 3 and renal replacement therapy (RRT). 105 (49.07%) patients developed AKI, including 21 (9.81%) progression to AKI stage 3 and 10 (4.67%) requiring RRT. The urine output decreased with the increasing severity of AKI. The urine output of AKI stage 3 did not significantly increase after the use of furosemide. The area under the receiver operator characteristic (ROC) curves for the total urine output in the first hour to predict progression to AKI stage 3 was 0.94 ( p  < 0.001). The ideal cutoff for predicting AKI progression during the first hour was a urine volume of less than 200 ml with a sensitivity of 90.48% and specificity of 86.53%. The area under the ROC curves for the total urine output in the six hours to predict progression to RRT was 0.944 ( p  < 0.001). The ideal cutoff was a urine volume of less than 500 ml with a sensitivity of 90% and specificity of 90.91%. Severe AKI after liver transplantation seriously affects the outcome of patients. Lack of furosemide responsiveness quickly and accurately predict AKI stage 3, and patients requiring RRT after the operation.