Biosynthesis of PP-V, a monascorubramine homologue, by Penicillium sp. AZ

The biosynthetic pathway of PP-V, a new monascorubramine homologue, was elucidated by 13C-labeling studies. The [1- 13C] of acetate was incorporated into 2-, 3a-, 4a-, 6-, 8-, 9-, 11-, 13-, 15-, 17-, and 19-Cs of PP-V, and the [2- 13C], into 3-, 4-, 5-, 8a-, 9a-, 10-, 12-, 14-, 16-, 18-, and 20-Cs....

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Bibliographic Details
Published inJournal of bioscience and bioengineering Vol. 90; no. 6; pp. 678 - 680
Main Authors Ogihara, Jun, Kato, Jun, Oishi, Kunio, Fujimoto, Yoshinori
Format Journal Article
LanguageEnglish
Published Amsterdarm Elsevier B.V 2000
Elsevier Science
Subjects
13C-acetate
azaphilone
Biological and medical sciences
Biology of microorganisms of confirmed or potential industrial interest
BIOSYNTHESIS
Biotechnology
Fundamental and applied biological sciences. Psychology
Mission oriented research
MONASCUS
PENICILLIUM
Physiology and metabolism
pigment
PIGMENTS
pigment
13C-acetate
Monascus
azaphilone
Penicillium
Fungi
Pigments
Ascomycetes
Biosynthesis
Metabolic pathway
Fungi Imperfecti
Thallophyta
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Summary:The biosynthetic pathway of PP-V, a new monascorubramine homologue, was elucidated by 13C-labeling studies. The [1- 13C] of acetate was incorporated into 2-, 3a-, 4a-, 6-, 8-, 9-, 11-, 13-, 15-, 17-, and 19-Cs of PP-V, and the [2- 13C], into 3-, 4-, 5-, 8a-, 9a-, 10-, 12-, 14-, 16-, 18-, and 20-Cs. These incorporation patterns coincide with those reported in the biosynthesis of a Monascus azaphilone pigment, monascorubrin.
Bibliography:F60
2001003538
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ISSN:1389-1723
1347-4421
DOI:10.1016/S1389-1723(00)90017-3