Trends in biosensing platforms for SARS-CoV-2 detection: A critical appraisal against standard detection tools

• Published in: Current opinion in colloid & interface science Vol. 52; p. 101418
• Main Authors: Aziz, Ayesha, Asif, Muhammad, Ashraf, Ghazala, Farooq, Umer, Yang, Qiaoli, Wang, Shenqi
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.04.2021
• Subjects: Biosensors; COVID-19; COVID-19 infection; Diagnostics; early diagnosis; Emerging techniques; lungs; Pandemic; people; reactive oxygen species; RNA; SARS-CoV-2; Severe acute respiratory syndrome coronavirus 2; COVID-19; Pandemic; SARS-CoV-2; Diagnostics; Biosensors; Emerging techniques
• ISSN: 1359-0294; 1879-0399; 1359-0294
• DOI: 10.1016/j.cocis.2021.101418

In this ongoing theme of coronavirus disease 2019 (COVID-19) pandemic, highly sensitive analytical testing platforms are extremely necessary to detect SARS-CoV-2 RNA and antiviral antibodies. To limit the viral spread, prompt and precise diagnosis is crucial to facilitate treatment and ensure effective isolation. Accurate detection of antibodies (IgG and IgM) is imperative to understand the prevalence of SARS-CoV-2 in public and to inspect the proportion of immune individuals. In this review, we demonstrate and evaluate some tests that have been used commonly to detect SARS-CoV-2. These include nucleic acid and serological tests for the detection of SARS-CoV-2 RNA and specific antibodies in infected people. Moreover, the vitality of biosensing technologies emphasizing on optical and electrochemical biosensors toward the detection of SARS-CoV-2 has also been discussed here. The early diagnosis of COVID-19 based on detection of reactive oxygen species overproduction because of virus-induced dysfunctioning of lung cells has also been highlighted. [Display omitted] •Standard diagnosis tools for SARS-CoV-2 detection.•Development in diagnostic tests for SARS-CoV-2 detection.•Emerging biosensing technologies for SARS-CoV-2 detection.•Real-time monitoring of SARS-CoV-2 from blood serum, nasal swab, and urine samples.