Parental transmission of HLA-DRB115 in multiple sclerosis

• Published in: Human genetics Vol. 122; no. 6; pp. 661 - 663
• Main Authors: Ramagopalan, Sreeram V., Herrera, Blanca M., Bell, Jordana T., Dyment, David A., DeLuca, Gabriele C., Lincoln, Matthew R., Orton, Sarah M., Chao, Michael J., Sadovnick, A. Dessa, Ebers, George C.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer-Verlag 2008; Springer; Springer Nature B.V
• Subjects: Biological and medical sciences; Biomedical and Life Sciences; Biomedicine; Child; Classical genetics, quantitative genetics, hybrids; Cohort Studies; Collaboration; DNA methylation; Epigenetics; Families & family life; Family; Female; Fundamental and applied biological sciences. Psychology; Gene Function; Genes; Genetic Predisposition to Disease; Genetics of eukaryotes. Biological and molecular evolution; Genotype; Haplotypes; Histocompatibility antigens; HLA histocompatibility antigens; HLA-DR Antigens - genetics; HLA-DRB1 Chains; Human; Human Genetics; Humans; Inheritance Patterns; Male; Medical genetics; Medical sciences; Metabolic Diseases; Molecular Medicine; Mothers; Multiple sclerosis; Multiple Sclerosis - genetics; Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis; Neurology; Parents; Regression analysis; Short Report; Siblings; United Kingdom > UK; Multiple Sclerosis; Northern European Descent; Conditional Logistic Regression; Multiple Sclerosis Susceptibility; Transmission Disequilibrium Test; Genetics; Nervous system diseases; Multiple sclerosis; Central nervous system disease; Transmission; Inflammatory disease
• ISSN: 0340-6717; 1432-1203
• DOI: 10.1007/s00439-007-0442-z

Multiple sclerosis (MS) is a complex trait in which HLA-DRB1*15 bearing MHC haplotypes increase risk of MS in people of Northern European descent. In this investigation of 7,334 individuals from 1,515 MS families, the largest cohort used to study the HLA-DRB1 locus to date, we analysed the transmission of HLA-DRB1*15 haplotypes stratified by sex of transmitting parent. A significant over transmission of HLA-DRB1*15 from mothers was observed ( χ 2  = 7.73, P  = 0.0054), suggesting that parent of origin effects at the MHC determine susceptibility to MS.