Body mass index, physical activity, and television time in relation to mortality risk among endometrial cancer survivors in the NIH-AARP Diet and Health Study cohort

• Published in: Cancer causes & control Vol. 27; no. 11; pp. 1403 - 1409
• Main Authors: Arem, Hannah, Pfeiffer, Ruth M., Moore, Steven C., Brinton, Louise A., Matthews, Charles E.
• Format: Journal Article
• Language: English
• Published: Cham Springer Science + Business Media 01.11.2016; Springer International Publishing; Springer Nature B.V
• Subjects: Aged; Biomedical and Life Sciences; Biomedicine; Body Mass Index; BRIEF REPORT; Cancer Research; Cohort Studies; Diet; Endometrial cancer; Endometrial Neoplasms - complications; Endometrial Neoplasms - mortality; Epidemiology; Exercise; Female; Hematology; Humans; Leisure Activities; Life Style; Middle Aged; Mortality; Obesity - complications; Oncology; Public Health; Risk Factors; Surveys and Questionnaires; Survivors; Television; United States > US; Body mass index; Endometrial cancer; Physical activity; Television; Mortality; Cancer survivorship
• ISSN: 0957-5243; 1573-7225
• DOI: 10.1007/s10552-016-0813-7

Purpose Endometrial cancer (EC) survivors are the second largest group of female cancer survivors in the USA, with high prevalence of obesity and physical inactivity. While higher pre-diagnosis body mass index (BMI) has been associated with higher all-cause and disease-specific mortality, pre-diagnosis physical activity has shown mixed evidence of an association with mortality. However, the association between BMI, physical activity, and TV viewing measured after diagnosis and mortality risk among EC survivors is unknown. Methods We identified 580 women with EC in the NIH-AARP Diet and Health Study who completed a post-diagnosis questionnaire on BMI, leisure time moderate- to vigorous-intensity physical activity (MVPA), and TV viewing. We used Cox proportional hazards regression to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for mortality. Results With a median follow-up time of 7.1 years, we observed 91 total deaths. We found a positive association between BMI ( HR 35 + vs. < 25 kg/m 2  = 2.14, 95% CI 1.08–4.24 and mortality, and no statistically significant association between TV viewing (HR 5+ vs. <3 h/day  = 1.46, 95% CI 0.86–2.46) and mortality nor MVPA with mortality (HR 15+ vs. 0 MET h/week  = 0.72, 95% CI 0.43–1.21) after adjusting for tumor characteristics and demographic factors. Further adjustment for lifestyle and health status attenuated BMI associations ( HR 35 + vs. < 25 kg/m 2  = 1.47, 95% CI 0.71–3.07), but strengthened the association between TV viewing and mortality (HR 5+ vs. <3 h/day  = 2.28, 95% CI 1.05–4.95). Conclusions Our results suggest that higher post-diagnosis BMI and TV viewing may be associated with higher mortality risk among EC patients, but that there may be complicated interrelationships between lifestyle factors of BMI, PA, and TV viewing and the mediating role of health status that need to be clarified.