Safety and tissue remodeling assay of small intestinal submucosa meshes using a modified porcine surgical hernia model

• Published in: Scientific reports Vol. 13; no. 1; p. 23108
• Main Authors: Liu, Chenghu, Lin, Zhenhua, Ruan, Wenting, Gai, Xiaoxiao, Qu, Qiujin, Wang, Changbin, Zhu, Fuyu, Sun, Xiaoxia, Zhang, Jian
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 03.01.2024; Nature Publishing Group; Nature Portfolio
• Subjects: 631/61/2035; 692/4017; Animal models; Animals; Biocompatibility; Cell viability; Chemotaxis; Cytotoxicity; Extracellular matrix; Hernia; Hernia, Ventral - surgery; Hernias; Herniorrhaphy - methods; Humanities and Social Sciences; Hybridization; Immunogenicity; Laparoscopy; Models, Animal; multidisciplinary; Prostheses and Implants; Safety; Science; Science (multidisciplinary); Small intestine; Swine; Tissues; Wound Healing

In studies to date, meshes based on extracellular matrix (ECM) have been extensively used in clinical applications. Unfortunately, little is known about the function of the immunogenic residual, absorbable profile during the tissue repair process. Moreover, there needs to be a recognized preclinical...