New vasorelaxant indole alkaloids, taberniacins A and B, from Tabernaemontana divaricata

Taberniacins A ( 1 ) and B ( 2 ), new indole alkaloids, were isolated from the stems of Tabernaemontana divaricata (Apocynaceae). Structure elucidation of 1 and 2 was based on spectroscopic methods and total synthesis. Each alkaloid showed vasorelaxant activity against phenylephrine-induced contract...

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Published inJournal of natural medicines Vol. 73; no. 3; pp. 627 - 632
Main Authors Hirasawa, Yusuke, Dai, Xin, Deguchi, Jun, Hatano, Shota, Sasaki, Tadahiro, Ohtsuka, Ruri, Nugroho, Alfarius Eko, Kaneda, Toshio, Morita, Hiroshi
Format Journal Article
LanguageEnglish
Published Singapore Springer Singapore 01.06.2019
Springer Nature B.V
Subjects
Biomedical and Life Sciences
Biomedicine
Complementary & Alternative Medicine
Flowers & plants
Herbal medicine
Humans
Indole Alkaloids - chemistry
Medicinal Chemistry
Molecular Structure
Pharmacology/Toxicology
Pharmacy
Phytochemicals
Plant Sciences
Rodents
Tabernaemontana - chemistry
Vasodilator Agents - pharmacology
Vasodilator Agents - therapeutic use
Veins & arteries
Taberniacin B
Taberniacin A
Vasorelaxant
Indole alkaloid
Tabernaemontana divaricata
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Abstract Taberniacins A ( 1 ) and B ( 2 ), new indole alkaloids, were isolated from the stems of Tabernaemontana divaricata (Apocynaceae). Structure elucidation of 1 and 2 was based on spectroscopic methods and total synthesis. Each alkaloid showed vasorelaxant activity against phenylephrine-induced contraction of isolated rat aorta.
AbstractList Taberniacins A (1) and B (2), new indole alkaloids, were isolated from the stems of Tabernaemontana divaricata (Apocynaceae). Structure elucidation of 1 and 2 was based on spectroscopic methods and total synthesis. Each alkaloid showed vasorelaxant activity against phenylephrine-induced contraction of isolated rat aorta.
Taberniacins A ( 1 ) and B ( 2 ), new indole alkaloids, were isolated from the stems of Tabernaemontana divaricata (Apocynaceae). Structure elucidation of 1 and 2 was based on spectroscopic methods and total synthesis. Each alkaloid showed vasorelaxant activity against phenylephrine-induced contraction of isolated rat aorta.
Author Hirasawa, Yusuke
Hatano, Shota
Nugroho, Alfarius Eko
Kaneda, Toshio
Dai, Xin
Deguchi, Jun
Ohtsuka, Ruri
Morita, Hiroshi
Sasaki, Tadahiro
Author_xml – sequence: 1
  givenname: Yusuke
  surname: Hirasawa
  fullname: Hirasawa, Yusuke
  organization: Faculty of Pharmaceutical Sciences, Hoshi University
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  givenname: Xin
  surname: Dai
  fullname: Dai, Xin
  organization: Faculty of Pharmaceutical Sciences, Hoshi University
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  givenname: Jun
  surname: Deguchi
  fullname: Deguchi, Jun
  organization: Faculty of Pharmaceutical Sciences, Hoshi University
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  givenname: Shota
  surname: Hatano
  fullname: Hatano, Shota
  organization: Faculty of Pharmaceutical Sciences, Hoshi University
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  surname: Sasaki
  fullname: Sasaki, Tadahiro
  organization: Faculty of Pharmaceutical Sciences, Hoshi University
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  fullname: Ohtsuka, Ruri
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  fullname: Kaneda, Toshio
  organization: Faculty of Pharmaceutical Sciences, Hoshi University
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  givenname: Hiroshi
  surname: Morita
  fullname: Morita, Hiroshi
  email: moritah@hoshi.ac.jp
  organization: Faculty of Pharmaceutical Sciences, Hoshi University
BackLink https://www.ncbi.nlm.nih.gov/pubmed/30847757$$D View this record in MEDLINE/PubMed
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Keywords Taberniacin B
Taberniacin A
Vasorelaxant
Indole alkaloid
Tabernaemontana divaricata
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Snippet Taberniacins A ( 1 ) and B ( 2 ), new indole alkaloids, were isolated from the stems of Tabernaemontana divaricata (Apocynaceae). Structure elucidation of 1...
Taberniacins A (1) and B (2), new indole alkaloids, were isolated from the stems of Tabernaemontana divaricata (Apocynaceae). Structure elucidation of 1 and 2...
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SubjectTerms Biomedical and Life Sciences
Biomedicine
Complementary & Alternative Medicine
Flowers & plants
Herbal medicine
Humans
Indole Alkaloids - chemistry
Medicinal Chemistry
Molecular Structure
Pharmacology/Toxicology
Pharmacy
Phytochemicals
Plant Sciences
Rodents
Tabernaemontana - chemistry
Vasodilator Agents - pharmacology
Vasodilator Agents - therapeutic use
Veins & arteries
Title New vasorelaxant indole alkaloids, taberniacins A and B, from Tabernaemontana divaricata
URI https://link.springer.com/article/10.1007/s11418-019-01293-9
https://www.ncbi.nlm.nih.gov/pubmed/30847757
https://www.proquest.com/docview/2230828239
https://search.proquest.com/docview/2189535766
Volume 73
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