New vasorelaxant indole alkaloids, taberniacins A and B, from Tabernaemontana divaricata

Taberniacins A ( 1 ) and B ( 2 ), new indole alkaloids, were isolated from the stems of Tabernaemontana divaricata (Apocynaceae). Structure elucidation of 1 and 2 was based on spectroscopic methods and total synthesis. Each alkaloid showed vasorelaxant activity against phenylephrine-induced contract...

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Published inJournal of natural medicines Vol. 73; no. 3; pp. 627 - 632
Main Authors Hirasawa, Yusuke, Dai, Xin, Deguchi, Jun, Hatano, Shota, Sasaki, Tadahiro, Ohtsuka, Ruri, Nugroho, Alfarius Eko, Kaneda, Toshio, Morita, Hiroshi
Format Journal Article
LanguageEnglish
Published Singapore Springer Singapore 01.06.2019
Springer Nature B.V
Subjects
Biomedical and Life Sciences
Biomedicine
Complementary & Alternative Medicine
Flowers & plants
Herbal medicine
Humans
Indole Alkaloids - chemistry
Medicinal Chemistry
Molecular Structure
Pharmacology/Toxicology
Pharmacy
Phytochemicals
Plant Sciences
Rodents
Tabernaemontana - chemistry
Vasodilator Agents - pharmacology
Vasodilator Agents - therapeutic use
Veins & arteries
Taberniacin B
Taberniacin A
Vasorelaxant
Indole alkaloid
Tabernaemontana divaricata
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Summary:Taberniacins A ( 1 ) and B ( 2 ), new indole alkaloids, were isolated from the stems of Tabernaemontana divaricata (Apocynaceae). Structure elucidation of 1 and 2 was based on spectroscopic methods and total synthesis. Each alkaloid showed vasorelaxant activity against phenylephrine-induced contraction of isolated rat aorta.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1340-3443
1861-0293
DOI:10.1007/s11418-019-01293-9