In vitro anti-HMPV activity of meroditerpenoids from marine alga Stypopodium zonale (Dictyotales)

• Published in: Molecules (Basel, Switzerland) Vol. 16; no. 10; pp. 8437 - 8450
• Main Authors: Mendes, Gabriella, Soares, Angélica Ribeiro, Sigiliano, Lorena, Machado, Fernanda, Kaiser, Carlos, Romeiro, Nelilma, Gestinari, Lísia, Santos, Norma, Romanos, Maria Teresa Villela
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 10.10.2011; MDPI
• Subjects: Acids; alga, antiviral; Animals; Antiviral Agents - chemistry; Antiviral Agents - pharmacology; Cell culture; Cell Line; Cytotoxicity; Dictyotaceae; Diterpenes - chemistry; Diterpenes - pharmacology; HMPV; Macaca mulatta; meroditerpenoids; Metapneumovirus - drug effects; Microbial Sensitivity Tests; Models, Molecular; Molecular Structure; Phaeophyceae; Real time; Respiratory syncytial virus; Ribavirin - pharmacology; Terpenes - chemistry; Terpenes - pharmacology; Toxicity; Virus Replication - drug effects; Viruses; Brazil; Rio de Janeiro Brazil
• ISSN: 1420-3049; 1420-3049
• DOI: 10.3390/molecules16108437

In this paper, we evaluated the antiviral activity against HMPV replication of crude extract of the marine algae Stypopodium zonale and of two meroditerpenoids obtained from it, atomaric acid and epitaondiol, and a methyl ester derivative of atomaric acid. Their selectivity indexes were 20.78, >56.81, 49.26 and 12.82, respectively. Compared to ribavirin, the substances showed a relatively low cytotoxicity on LLC-MK2 cells, with a significant antiviral activity, inhibiting at least 90% of viral replication in vitro, which demonstrates the potential of these marine natural products to combat infections caused by HMPV in vitro.