Reliability and validity of the Cancer Therapy Satisfaction Questionnaire in lung cancer

• Published in: Quality of life research Vol. 25; no. 1; pp. 71 - 80
• Main Authors: Cheung, K., de Mol, M., Visser, S., Den Oudsten, B. L., Stricker, B. H., Aerts, J. G. J. V.
• Format: Journal Article
• Language: English
• Published: Cham Springer 01.01.2016; Springer International Publishing; Springer Nature B.V
• Subjects: Adenocarcinoma - psychology; Adenocarcinoma of Lung; Aged; Cancer; Cancer therapies; Carcinoma, Non-Small-Cell Lung - psychology; Chemotherapy; Construct validity; Female; Hospitals; Humans; INSTRUMENT DEVELOPMENT; Lung cancer; Lung diseases; Lung neoplasms; Lung Neoplasms - psychology; Male; Mathematical validity; Medical prognosis; Medical treatment; Medicine; Medicine & Public Health; Middle Aged; Neoplasm Staging; Oncology; Patient Satisfaction; Personal Satisfaction; Psychometrics; Public Health; Quality of life; Quality of Life - psychology; Quality of Life Research; Quantitative psychology; Questionnaires; Reproducibility of Results; Side effects; Sociodemographics; Sociology; Surveys and Questionnaires; Translations; Validation studies; Validity; World Health Organization; Expectations; Validity; Chemotherapy; Lung cancer; Satisfaction; Cancer Therapy Satisfaction Questionnaire
• ISSN: 0962-9343; 1573-2649
• DOI: 10.1007/s11136-015-1062-z

Purpose To test the reliability and validity of the Cancer Treatment Satisfaction Questionnaire (CTSQ), to assess its relation with quality of life (QoL), and to assess the interpretability of the domain scores in lung cancer patients receiving intravenous chemotherapy. Methods Patients with stage IIIB and IV non-squamous non-small cell lung carcinoma treated with pemetrexed were enrolled in our study. They completed the 16-item CTSQ and two other (health-related) QoL questionnaires. Information about sociodemographic characteristics, cancer stage, and the experience of adverse events was collected. Internal consistency, construct validity, and clinical interpretability were calculated. Results Fifty-five patients completed the CTSQ. Correlations of the CTSQ items with its domain were all above 0.40. A high correlation between item 8 and the expectations of therapy and satisfaction with therapy domain was observed (0.50 and 0.48, respectively). The CTSQ domains demonstrated good internal consistency and low to moderate correlations of the CTSQ with the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-C30 and World Health Organization Quality of Life-BREF. No significant differences in mean domain scores were observed in relation to the number and severity of different adverse events and chemotherapy-related adverse events. Conclusions The Dutch version of the CTSQ was found to be a reliable and valid instrument to assess satisfaction and expectations of treatment in lung cancer patients receiving intravenous chemotherapy. Furthermore, the CTSQ proved to be of additional informative value as not all of its domains correlated with the various domains of the existing HRQoL instruments.