Morphogen gradient interpretation

A morphogen gradient is an important concept in developmental biology, because it describes a mechanism by which the emission of a signal from one part of an embryo can determine the location, differentiation and fate of many surrounding cells. The value of this idea has been clear for over half a c...

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Published inNature (London) Vol. 413; no. 6858; pp. 797 - 803
Main Authors Gurdon, J. B, Bourillot, P.-Y
Format Journal Article
LanguageEnglish
Published England Nature Publishing Group 25.10.2001
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Abstract A morphogen gradient is an important concept in developmental biology, because it describes a mechanism by which the emission of a signal from one part of an embryo can determine the location, differentiation and fate of many surrounding cells. The value of this idea has been clear for over half a century, but only recently have experimental systems and methods of analysis progressed to the point where we begin to understand how a cell can sense and respond to tiny changes in minute concentrations of extracellular signalling factors.
AbstractList A morphogen gradient is an important concept in developmental biology, because it describes a mechanism by which the emission of a signal from one part of an embryo can determine the location, differentiation and fate of many surrounding cells. The value of this idea has been clear for over half a century, but only recently have experimental systems and methods of analysis progressed to the point where we begin to understand how a cell can sense and respond to tiny changes in minute concentrations of extracellular signalling factors.
Audience Academic
Author Bourillot, P.-Y
Gurdon, J. B
Author_xml – sequence: 1
  givenname: J. B
  surname: Gurdon
  fullname: Gurdon, J. B
– sequence: 2
  givenname: P.-Y
  surname: Bourillot
  fullname: Bourillot, P.-Y
BackLink https://www.ncbi.nlm.nih.gov/pubmed/11677596$$D View this record in MEDLINE/PubMed
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PublicationYear 2001
Publisher Nature Publishing Group
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Snippet A morphogen gradient is an important concept in developmental biology, because it describes a mechanism by which the emission of a signal from one part of an...
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SubjectTerms Animals
Cell Differentiation - physiology
Cells
Cellular biology
Chemotactic Factors - physiology
Drosophila
Drosophila - embryology
Embryonic Induction
Embryos
Emissions
Gene Expression Regulation, Developmental
Molecules
Morphogenesis - genetics
Morphogenesis - physiology
Signal Transduction
Wings, Animal - embryology
Title Morphogen gradient interpretation
URI http://dx.doi.org/10.1038/35101500
https://www.ncbi.nlm.nih.gov/pubmed/11677596
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