Morphogen gradient interpretation

A morphogen gradient is an important concept in developmental biology, because it describes a mechanism by which the emission of a signal from one part of an embryo can determine the location, differentiation and fate of many surrounding cells. The value of this idea has been clear for over half a c...

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Bibliographic Details
Published inNature (London) Vol. 413; no. 6858; pp. 797 - 803
Main Authors Gurdon, J. B, Bourillot, P.-Y
Format Journal Article
LanguageEnglish
Published England Nature Publishing Group 25.10.2001
Subjects
Animals
Cell Differentiation - physiology
Cells
Cellular biology
Chemotactic Factors - physiology
Drosophila
Drosophila - embryology
Embryonic Induction
Embryos
Emissions
Gene Expression Regulation, Developmental
Molecules
Morphogenesis - genetics
Morphogenesis - physiology
Signal Transduction
Wings, Animal - embryology
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Summary:A morphogen gradient is an important concept in developmental biology, because it describes a mechanism by which the emission of a signal from one part of an embryo can determine the location, differentiation and fate of many surrounding cells. The value of this idea has been clear for over half a century, but only recently have experimental systems and methods of analysis progressed to the point where we begin to understand how a cell can sense and respond to tiny changes in minute concentrations of extracellular signalling factors.
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ISSN:0028-0836
1476-4687
DOI:10.1038/35101500