Reproductive hormones and bone mineral density in women runners

• Published in: Journal of applied physiology (1985) Vol. 72; no. 6; p. 2149
• Main Authors: Snead, D B, Weltman, A, Weltman, J Y, Evans, W S, Veldhuis, J D, Varma, M M, Teates, C D, Dowling, E A, Rogol, A D
• Format: Journal Article
• Language: English
• Published: United States 01.06.1992
• Subjects: Adolescent; Adult; Amenorrhea - physiopathology; Bone Density - physiology; Dehydroepiandrosterone - analogs & derivatives; Dehydroepiandrosterone - blood; Dehydroepiandrosterone Sulfate; Estradiol - blood; Exercise - physiology; Female; Gonadal Steroid Hormones - blood; Gonadal Steroid Hormones - physiology; Humans; Menstruation - physiology; Oligomenorrhea - physiopathology; Progesterone - blood; Running
• ISSN: 8750-7587; 1522-1601
• DOI: 10.1152/jappl.1992.72.6.2149

We examined the relationships among reproductive hormone concentrations and bone mineral density (BMD) in 43 women runners classified as eumenorrheic (n = 24), oligomenorrheic (n = 8), or amenorrheic (n = 11). Results were compared with a eumenorrheic nonrunner control group (n = 11). Serum 17 beta-estradiol, progesterone, and dehydroepiandrosterone sulfate concentrations were determined in daily blood samples for 21 days, and integrated concentrations (areas under the curve) were calculated. BMD was assessed at the lumbar spine and proximal femur by dual-photon absorptiometry. As expected, 17 beta-estradiol, progesterone, and lumbar spine BMD were higher in the control and eumenorrheic runner groups than in the oligomenorrheic and amenorrheic runner groups (P less than 0.05). Progesterone concentration was significantly correlated with lumbar spine BMD in the eumenorrheic runners (r = 0.61). None of the steroid hormones was significantly related to BMD in the oligomenorrheic/amenorrheic group. The present data suggest that circulating levels of gonadal steroid hormones affect axial BMD in eumenorrheic runners.