The roles of growth factors and hormones in the regulation of muscle satellite cells for cultured meat production

• Published in: Journal of animal science and technology Vol. 65; no. 1; pp. 16 - 31
• Main Authors: Ahmad, Syed Sayeed, Chun, Hee Jin, Ahmad, Khurshid, Shaikh, Sibhghatulla, Lim, Jeong Ho, Ali, Shahid, Han, Sung Soo, Hur, Sun Jin, Sohn, Jung Hoon, Lee, Eun Ju, Choi, Inho
• Format: Journal Article
• Language: English
• Published: Korea (South) Korean Society of Animal Sciences and Technology 01.01.2023; 한국축산학회
• Subjects: Cultured meat; Growth factors; Hormones; Muscle satellite cells; Myogenesis; Review; 축산학; Muscle satellite cells; Hormones; Growth factors; Myogenesis; Cultured meat
• ISSN: 2055-0391; 2672-0191; 2093-6281
• DOI: 10.5187/jast.2022.e114

Cultured meat is a potential sustainable food generated by the myogenesis of muscle satellite (stem) cells (MSCs). The self-renewal and differentiation properties of MSCs are of primary interest for cultured meat production. MSC proliferation and differentiation are influenced by a variety of growth factors such as insulin-like growth factors (IGF-1 and IGF-2), transforming growth factor beta (TGF-β), fibroblast growth factors (FGF-2 and FGF-21), platelet-derived growth factor (PDGF) and hepatocyte growth factor (HGF) and by hormones like insulin, testosterone, glucocorticoids, and thyroid hormones. In this review, we investigated the roles of growth factors and hormones during cultured meat production because these factors provide signals for MSC growth and structural stability. The aim of this article is to provide the important idea about different growth factors such as FGF (enhance the cell proliferation and differentiation), IGF-1 (increase the number of myoblasts), PDGF (myoblast proliferation), TGF-β1 (muscle repair) and hormones such as insulin (cell survival and growth), testosterone (muscle fiber size), dexamethasone (myoblast proliferation and differentiation), and thyroid hormones (amount and diameter of muscle fibers and determine the usual pattern of fiber distributions) as media components during myogenesis for cultured meat production.