Experimental Model of Combined Pain and Depression Status in Rats

• Published in: Bulletin of experimental biology and medicine Vol. 149; no. 4; pp. 479 - 484
• Main Authors: Krupina, N. A, Khlebnikova, N. N, Orlova, I. N, Grafova, V. N, Smirnova, V. S, Rodina, V. I, Kukushkin, M. L, Kryzhanovsky, G. N
• Format: Journal Article
• Language: English; Russian
• Published: Boston Boston : Springer US 01.10.2010; Springer US; Springer; Springer Nature B.V
• Subjects: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animal behavior; Animals; Anxiety - etiology; Axotomy; Behavior, Animal - drug effects; Biomedical and Life Sciences; Biomedicine; Care and treatment; Cell Biology; Depression - chemically induced; Depression, Mental; depressive syndrome; Drinking Behavior - drug effects; Internal Medicine; Laboratory Medicine; Male; Methods; Models, Animal; Motor Activity - drug effects; neurogenic pain syndrome; Pain; Pathology; Rats; Rats, Wistar; Sciatic Neuropathy - complications; model; rats; neurogenic pain syndrome; depressive syndrome
• ISSN: 0007-4888; 1573-8221
• DOI: 10.1007/s10517-010-0975-3

Combined pain and depression status in rats was created by inducing experimental depressive syndrome (by subchronic injection of MPTP proneurotoxin) in animals with manifest and developing neurogenic pain syndrome induced by preliminary crossing of the sciatic nerve in the hind limb. The neurogenic pain syndrome augmented by some parameters the depressive symptoms and provoked manifestation of signs of depressive behavior in animals treated with saline.