Efficacy and safety of a submucosal injection solution of sodium alginate for endoscopic resection in a porcine model

• Published in: Scientific reports Vol. 14; no. 1; p. 4592
• Main Authors: Jung, Kyung Uk, Lee, Yeon Jae, Jang, Jae-Young, Cho, Joo Young
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 26.02.2024; Nature Publishing Group; Nature Portfolio
• Subjects: 631/67/1504; 692/4020; 692/4020/2223; Alginates; Alginic acid; Animal models; Animals; Endoscopy; Endoscopy - methods; Gastric Mucosa - surgery; Humanities and Social Sciences; Hyaluronic Acid; Injection; Injections; multidisciplinary; Saline Solution; Science; Science (multidisciplinary); Sodium; Sodium alginate; Sodium hyaluronate; Statistical analysis; Swine
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-024-55226-y

Endoscopic resection techniques require the use of submucosal injection. Normal saline and sodium hyaluronate solutions are mainly used for this purpose, but an ideal solution has not yet been developed. The aim of this study was to assess a new solution, MC-003—a novel submucosal injection solution developed with sodium alginate as the main ingredient. Normal saline, a commercial sodium hyaluronate solution (Endo-Ease), and MC-003 were examined. A total of 18 gastric submucosal cushions were created in the stomachs of six pigs. The height of mucosal elevation was measured sequentially using endoscopic sonography. After euthanizing the animals either 2 h or 5 days after the procedure, pathologic examination was performed for each injection site. Although not statistically significant over the entire study period, MC-003 showed a superior result to normal saline and an equivalent result to Endo-Ease in the submucosal cushion height and its rate of decrease. There were no adverse outcomes after injection of the three solutions and there was no pathologically identified detrimental change in the resected specimens. MC-003 creates a sufficient submucosal fluid cushion without apparent tissue damage. It can be considered as an effective submucosal injection material.