Structural and functional photoacoustic molecular tomography aided by emerging contrast agents
Photoacoustic tomography (PAT) can offer structural, functional and molecular contrasts at scalable observation level. By ultrasonically overcoming the strong optical scattering, this imaging technology can reach centimeters penetration depth while retaining high spatial resolution in biological tis...
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| Published in | Chemical Society reviews Vol. 43; no. 2; pp. 7132 - 717 |
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| Main Authors | , |
| Format | Journal Article |
| Language | English |
| Published |
England
01.01.2014
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| Subjects | |
| Online Access | Get full text |
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| Summary: | Photoacoustic tomography (PAT) can offer structural, functional and molecular contrasts at scalable observation level. By ultrasonically overcoming the strong optical scattering, this imaging technology can reach centimeters penetration depth while retaining high spatial resolution in biological tissue. Recent extensive research has been focused on developing new contrast agents to improve the imaging sensitivity, specificity and efficiency. These emerging materials have substantially accelerated PAT applications in signal sensing, functional imaging, biomarker labeling and therapy monitoring
etc.
Here, the potentials of different optical probes as PAT contrast agents were elucidated. We first describe the instrumental embodiments and the measured functional parameters, then focus on emerging contrast agent-based PAT applications, and finally discuss the challenges and prospects.
Emerging optical contrast agents substantially advance photoacoustic molecular tomography on sensitivity and specificity enhancement, structural and functional imaging. |
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| Bibliography: | Dr Liming Nie earned his BS degree in 2005 and PhD degree in 2010, both in optics, from South China Normal University. His PhD project was focused on photoacoustic/thermoacoustic tomography system development and related biomedical applications. In August 2010 to September 2012, Dr Nie received postdoctoral training in the Optical Imaging Lab under the mentorship of Dr Lihong V. Wang at Washington University in St. Louis. His projects involved functional photoacoustic tomography of the primate brain and the reconstruction correction of acoustic aberration. From October 2012 to 2013, he worked on photoacoustic molecular imaging/microscopy in the Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institutes of Health (NIH). Currently he works in the Center for Molecular Imaging and Translational Medicine (CMITM), Xiamen University. His research interests are the development of novel biomedical imaging techniques including photoacoustic imaging, fluorescence imaging, and biomarker sensing. One of his aims is to provide effective and low-cost imaging methods and instruments for early-stage disease diagnosis and treatment monitoring. Xiaoyuan Chen received his PhD in Chemistry from the University of Idaho in 1999. He joined the University of Southern California as an Assistant Professor of Radiology in 2002. He then moved to Stanford University in 2004 and was promoted to Associate Professor in 2008. In the summer of 2009, he joined the Intramural Research Program of the NIBIB as a Senior Investigator and Chief of the Laboratory of Molecular Imaging and Nanomedicine (LOMIN). Dr Chen has published over 400 papers and numerous books and book chapters. He sits on the editorial board of over 10 peer-reviewed journals and is the founding editor of journal Theranostics. His lab focuses on developing molecular imaging probes and nanotechnologies for early diagnosis of disease, monitoring therapy responses, and guiding drug discovery/development. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23 |
| ISSN: | 0306-0012 1460-4744 1460-4744 |
| DOI: | 10.1039/c4cs00086b |