Multicellular dynamics during epithelial elongation

The reorganization of multicellular populations to produce an elongated tissue structure is a conserved mechanism for shaping the body axis and several organ systems. In the Drosophila germband epithelium, this process is accompanied by the formation of a planar polarized network of junctional and c...

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Bibliographic Details
Published inSeminars in cell & developmental biology Vol. 19; no. 3; pp. 263 - 270
Main Authors Zallen, Jennifer A., Blankenship, J. Todd
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.06.2008
Subjects
Adhesion
Animals
Axis elongation
Cell Adhesion
Cell Differentiation
Cell Polarity
Cytoskeleton - metabolism
Drosophila
Drosophila melanogaster - cytology
Epithelial Cells - cytology
Morphogenesis
Polarity
Morphogenesis
Polarity
Axis elongation
Adhesion
Drosophila
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Summary:The reorganization of multicellular populations to produce an elongated tissue structure is a conserved mechanism for shaping the body axis and several organ systems. In the Drosophila germband epithelium, this process is accompanied by the formation of a planar polarized network of junctional and cytoskeletal proteins in response to striped patterns of gene expression. Actomyosin cables and adherens junctions are dynamically remodeled during intercalation, providing the basis for polarized cell behavior. Quantitative analysis of cell behavior in living embryos reveals unexpected cell population dynamics that include the formation of multicellular rosette structures as well as local neighbor exchange.
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ISSN:1084-9521
1096-3634
DOI:10.1016/j.semcdb.2008.01.005