Predicting the clinical outcome of congenital unilateral ureteropelvic junction obstruction in newborn by urinary proteome analysis

• Published in: Nature Medicine Vol. 12; no. 4; pp. 398 - 400
• Main Authors: Schanstra, Joost P, Decramer, Stephane, Wittke, Stefan, Mischak, Harald, Zürbig, Petra, Walden, Michael, Bouissou, François, Bascands, Jean-Loup
• Format: Journal Article Magazine Article
• Language: English
• Published: United States Nature Publishing Group 01.04.2006
• Subjects: Biological Markers; Biomarkers - urine; Case-Control Studies; Clinical outcomes; Double-Blind Method; Female; Human health and pathology; Humans; Infant; Infant, Newborn; Kidney Pelvis; Kidney Pelvis - pathology; Life Sciences; Male; Mass Spectrometry; Medical disorders; Neonatal care; Neonates; Peptides; Prognosis; Prospective Studies; Proteome; Proteome - analysis; Reference Standards; Reproducibility of Results; Severity of Illness; Severity of Illness Index; Specimen Handling; Time Factors; Ureteral Obstruction - congenital; Ureteral Obstruction - diagnosis; Ureteral Obstruction - metabolism; Ureteral Obstruction - pathology; Ureteral Obstruction - physiopathology; Urine; Urology and Nephrology
• ISSN: 1078-8956; 1546-170X; 1744-7933
• DOI: 10.1038/nm1384

We analyzed urinary polypeptides from individuals with neonatal ureteropelvic junction (UPJ) obstruction to predict which individuals with this condition will evolve toward obstruction that needs surgical correction. We identified polypeptides that enabled diagnosis of the severity of obstruction and validated these biomarkers in urine collected in a prospective blinded study. Using these noninvasive biomarkers, we were able to predict, several months in advance and with 94% precision, the clinical evolution of neonates with UPJ obstruction.