Neural stem cells improve intracranial nanoparticle retention and tumor-selective distribution

The purpose of this work is to determine if tumor-tropic neural stem cells (NSCs) can improve the tumor-selective distribution and retention of nanoparticles (NPs) within invasive brain tumors. Streptavidin-conjugated, polystyrene NPs are surface-coupled to biotinylated human NSCs. These NPs are lar...

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Bibliographic Details
Published inFuture oncology (London, England) Vol. 10; no. 3; pp. 401 - 415
Main Authors Mooney, Rachael, Weng, Yiming, Tirughana-Sambandan, Revathiswari, Valenzuela, Valerie, Aramburo, Soraya, Garcia, Elizabeth, Li, Zhongqi, Gutova, Margarita, Annala, Alexander J, Berlin, Jacob M, Aboody, Karen S
Format Journal Article
LanguageEnglish
Published England Future Medicine Ltd 01.02.2014
Subjects
Animals
Brain Neoplasms - metabolism
Care and treatment
Cell Line, Tumor
Cell Movement
Cell Survival
cellular therapy
Drug Carriers - administration & dosage
Drug Carriers - chemistry
Drug Carriers - metabolism
Drug delivery systems
glioma
Glioma - metabolism
Gliomas
Humans
Mice
Mice, SCID
nanoparticles
Nanoparticles - administration & dosage
Nanoparticles - chemistry
Nanoparticles - metabolism
Neoplasm Transplantation
neural stem cell
Neural Stem Cells - physiology
Neural Stem Cells - transplantation
Particle Size
Physiological aspects
stem cell carriers
Stem cells
targeted delivery
Tissue Distribution
tropism
United States
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Summary:The purpose of this work is to determine if tumor-tropic neural stem cells (NSCs) can improve the tumor-selective distribution and retention of nanoparticles (NPs) within invasive brain tumors. Streptavidin-conjugated, polystyrene NPs are surface-coupled to biotinylated human NSCs. These NPs are large (798 nm), yet when conjugated to tropic cells, they are too large to passively diffuse through brain tissue or cross the blood-tumor barrier. NP distribution and retention was quantified 4 days after injections located either adjacent to an intracerebral glioma, in the contralateral hemisphere, or intravenously. In all three injection paradigms, NSC-coupled NPs exhibited significantly improved tumor-selective distribution and retention over free-NP suspensions. These results provide proof-of-principle that NSCs can facilitate the tumor-selective distribution of NPs, a platform useful for improving intracranial drug delivery.
Bibliography:Authors contributed equally
ISSN:1479-6694
1744-8301
DOI:10.2217/fon.13.217