Association between testosterone levels and the metabolic syndrome in adult men

• Published in: The aging male Vol. 17; no. 3; pp. 161 - 165
• Main Authors: Grosman, Halina, Rosales, Mónica, Fabre, Bibiana, Nolazco, Carlos, Mazza, Osvaldo, Berg, Gabriela, Mesch, Viviana
• Format: Journal Article
• Language: English
• Published: England Informa UK Ltd 01.09.2014; Taylor & Francis; Taylor & Francis Ltd
• Subjects: Adults; Aged; Body Mass Index; Cholesterol - blood; Cholesterol - physiology; HDL-cholesterol; Humans; Hypertension - blood; hypogonadism; insulin resistance; Male; Medical screening; Mens health; Metabolic syndrome; Metabolic Syndrome - blood; Metabolic Syndrome - physiopathology; Middle Aged; Older people; Prostate cancer; Testosterone; Testosterone - blood; Testosterone - physiology; triglycerides; Triglycerides - blood; Triglycerides - physiology; waist circumference; Waist Circumference - physiology; hypogonadism; triglycerides; waist circumference; insulin resistance; HDL-cholesterol
• ISSN: 1368-5538; 1473-0790
• DOI: 10.3109/13685538.2014.913561

Abstract Objective: To evaluate the relationship between testosterone levels and the metabolic syndrome (MS) in men older than 45 years. Methods: Six hundred and sixty men (45-70 years) selected from 2906 participants of a population screening for prostate cancer were included in this study. Testosterone and the components of MS were assessed in all men. MS was diagnosed according to NCEP-ATP III criteria. Triglycerides (TG)/HDL-cholesterol (chol) index was calculated. Results: The presence of MS was inversely associated with testosterone (χ2, p < 0.001), independently of age (OR 0.802, CI 95%: 0.724-0.887, p < 0.0001). Hypertension was the most frequent abnormality observed followed by elevated TG and waist circumference (WC). Testosterone correlated positively with HDL-chol (r: 0.14, p < 0.0001) and negatively with body mass index (BMI)(r: −0.29, p < 0.0001), WC (r: −0.26, p < 0.0001), TG (r: −0.20, p < 0.0001), TG/HDL-chol (r: −0.20, p < 0.0001), glucose (r: −0.11, p = 0.005) and MS score (r: −0.23, p < 0.0001). Conclusions: Our results show that in men older than 45 years, as long as testosterone levels decline, the prevalence of MS increases, independently of age. The correlations found between testosterone and four of the five components of MS, as well as with BMI and TG/HDL-chol ratio, a surrogate marker of insulin resistance, suggest considering male hypogonadism as a determinant of developmental abnormalities typical of MS.