Oncologic relevance of genetic alterations in sporadic synchronous and solitary colorectal cancer: a retrospective multicenter study
Abstract Background Oncologic impact of genetic alteration across synchronous colorectal cancer (CRC) still remains unclear. This study aimed to compare the oncologic relevance according to genetic alteration between synchronous and solitary CRC with performing systematic review. Methods Multicenter...
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Published in | BMC gastroenterology Vol. 23; no. 1; pp. 1 - 297 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
London
BioMed Central Ltd
04.09.2023
BioMed Central BMC |
Subjects | |
Online Access | Get full text |
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Summary: | Abstract
Background
Oncologic impact of genetic alteration across synchronous colorectal cancer (CRC) still remains unclear. This study aimed to compare the oncologic relevance according to genetic alteration between synchronous and solitary CRC with performing systematic review.
Methods
Multicenter retrospective analysis was performed for CRC patients with curative resection. Genetic profiling was consisted of microsatellite instability (MSI) testing,
RAS
(K-ras, and N-ras), and
BRAF
(v-Raf murine sarcoma viral oncogene homolog B1) V600E mutation. Multivariate analyses were conducted using logistic regression for synchronicity, and Cox proportional hazard model with stage-adjusting for overall survival (OS) and disease-free survival (DFS).
Results
It was identified synchronous (
n
= 36) and solitary (
n
= 579) CRC with similar base line characteristics.
RAS
mutation was associated to synchronous CRC with no relations of MSI and
BRAF
. During median follow up of 77.8 month, Kaplan–meier curves showed significant differences according to MSI-high for OS, and in
RAS
, and
BRAF mutation
for DFS, respectively. In multivariable analyses,
RAS
and
BRAF
mutation were independent factors (
RAS
, HR = 1.808, 95% CI = 1.18–2.77,
p
= 0.007;
BRAF
, HR = 2.417, 95% CI = 1.32–4.41,
p
= 0.004). Old age was independent factor for OS (HR = 3.626, 95% CI = 1.09–12.00,
p
= 0.035).
Conclusion
This study showed that oncologic outcomes might differ according to mutation burden characterized by
RAS, BRAF
, and MSI between synchronous CRC and solitary CRC. In addition, our systematic review highlighted a lack of data and much heterogeneity in genetic characteristics and survival outcomes of synchronous CRC relative to that of solitary CRC. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1471-230X 1471-230X |
DOI: | 10.1186/s12876-023-02937-7 |