The impact of CREBRF rs373863828 Pacific-variant on infant body composition

• Published in: Scientific reports Vol. 14; no. 1; p. 8825
• Main Authors: Amitrano, Francesca, Krishnan, Mohanraj, Murphy, Rinki, Okesene-Gafa, Karaponi A. M., Ji, Maria, Thompson, John M. D., Taylor, Rennae S., Merriman, Tony R., Rush, Elaine, McCowan, Megan, McCowan, Lesley M. E., McKinlay, Christopher J. D.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 17.04.2024; Nature Publishing Group; Nature Portfolio
• Subjects: 631/136/3194; 692/308/2056; 692/308/3187; 692/699/2743/137; 692/699/2743/137/1926; 692/699/2743/137/773; 692/699/2743/393; Adult; Alleles; Body Composition; Body fat; Body Mass Index; Diabetes mellitus; Diabetes, Gestational; Female; Gestational diabetes; Humanities and Social Sciences; Humans; Infant; Infants; Maori People; multidisciplinary; Obesity; Pregnancy; Prospective Studies; Science; Science (multidisciplinary); Secondary analysis
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-024-59417-5

In Māori and Pacific adults, the CREBRF rs373863828 minor (A) allele is associated with increased body mass index (BMI) but reduced incidence of type-2 and gestational diabetes mellitus. In this prospective cohort study of Māori and Pacific infants, nested within a nutritional intervention trial for pregnant women with obesity and without pregestational diabetes, we investigated whether the rs373863828 A allele is associated with differences in growth and body composition from birth to 12–18 months’ corrected age. Infants with and without the variant allele were compared using generalised linear models adjusted for potential confounding by gestation length, sex, ethnicity and parity, and in a secondary analysis, additionally adjusted for gestational diabetes. Carriage of the rs373863828 A allele was not associated with altered growth and body composition from birth to 6 months. At 12–18 months, infants with the rs373863828 A allele had lower whole-body fat mass [FM 1.4 (0.7) vs. 1.7 (0.7) kg, aMD −0.4, 95% CI −0.7, 0.0, P = 0.05; FM index 2.2 (1.1) vs. 2.6 (1.0) kg/m 2 aMD −0.6, 95% CI −1.2,0.0, P = 0.04]. However, this association was not significant after adjustment for gestational diabetes, suggesting that it may be mediated, at least in part, by the beneficial effect of CREBRF rs373863828 A allele on maternal glycemic status.