Synthesis of substituted 1,4-diazepines and 1,5-benzodiazepines using an efficient heteropolyacid-catalyzed procedure

An efficient and improved procedure for the synthesis of 1,4-diazepine and 1,5-benzodiazepine derivatives via the reaction of ketimine intermediates with aldehydes in the presence of Keggin-type heteropolyacids (HPAs) was developed. High yields and short reaction times were obtained for both electro...

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Published inMolecules (Basel, Switzerland) Vol. 16; no. 1; pp. 92 - 99
Main Authors Kaoua, Rachedine, Bennamane, Norah, Bakhta, Saliha, Benadji, Sihame, Rabia, Cherifa, Nedjar-Kolli, Bellara
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 28.12.2010
MDPI
Subjects
1,3-aminomethyl propane
1,4-diazepine
1,5-benzodiazepine
Acids - chemistry
Azepines - chemical synthesis
Azepines - chemistry
Benzodiazepines
Catalysis
dehydroacetic acid
heteropolyacids
Organic chemistry
orthophenylene diamine
Algeria
Algiers Algeria
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Summary:An efficient and improved procedure for the synthesis of 1,4-diazepine and 1,5-benzodiazepine derivatives via the reaction of ketimine intermediates with aldehydes in the presence of Keggin-type heteropolyacids (HPAs) was developed. High yields and short reaction times were obtained for both electron-releasing and electron-withdrawing substituted 1,4-diazepine  and 1,5-benzodiazepines derivatives.
Bibliography:ObjectType-Article-1
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ISSN:1420-3049
1420-3049
DOI:10.3390/molecules16010092