THE AURACHINS, NEW QUINOLINE ANTIBIOTICS FROM MYXOBACTERIA: PRODUCTION, PHYSICO-CHEMICAL AND BIOLOGICAL PROPERTIES

The aurachins, new quinoline alkaloids, were extracted with acetone from the biomass of the myxobacterium, Stigmatella aurantiaca strain Sg a!5 and purified by column chromatography. The four described aurachins A, B, C and D, were inhibitory for Gram-positive bacteria and a few yeasts and molds. Th...

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Bibliographic Details
Published inJournal of antibiotics Vol. 40; no. 3; pp. 258 - 265
Main Authors KUNZE, BRIGITTE, HÖFLE, GERHARD, REICHENBACH, HANS
Format Journal Article
LanguageEnglish
Published Japan JAPAN ANTIBIOTICS RESEARCH ASSOCIATION 1987
Subjects
Anti-Bacterial Agents - isolation & purification
Anti-Bacterial Agents - pharmacology
Chemical Phenomena
Chemistry
Chromatography, High Pressure Liquid
Chromatography, Thin Layer
Fermentation
Microbial Sensitivity Tests
Myxococcales - metabolism
Quinolines - isolation & purification
Quinolines - pharmacology
Quinolones
Spectrophotometry, Infrared
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Summary:The aurachins, new quinoline alkaloids, were extracted with acetone from the biomass of the myxobacterium, Stigmatella aurantiaca strain Sg a!5 and purified by column chromatography. The four described aurachins A, B, C and D, were inhibitory for Gram-positive bacteria and a few yeasts and molds. They blocked NADH oxidation in beef heart submitochondrial particles.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.40.258