Ability of FDG-PET/CT in the detection of gallbladder cancer

• Published in: Journal of surgical oncology Vol. 109; no. 3; pp. 218 - 224
• Main Authors: Ramos-Font, Carlos, Gómez-Rio, Manuel, Rodríguez-Fernández, Antonio, Jiménez-Heffernan, Amelia, Sánchez, Rocío Sánchez, Llamas-Elvira, Jose Manuel
• Format: Journal Article
• Language: English
• Published: United States Blackwell Publishing Ltd 01.03.2014; Wiley Subscription Services, Inc
• Subjects: Adenocarcinoma - diagnosis; Adenocarcinoma, Mucinous - diagnosis; Adult; Aged; Aged, 80 and over; Carcinoid Tumor - diagnosis; Carcinoma, Adenosquamous - diagnosis; diagnostic accuracy; Female; fluorodeoxiglucose F18; Fluorodeoxyglucose F18; gallbladder neoplasm; Gallbladder Neoplasms - diagnosis; Gallbladder Neoplasms - diagnostic imaging; Gallbladder Neoplasms - pathology; Humans; Male; Middle Aged; Multimodal Imaging - methods; Neoplasm Staging; Positron-Emission Tomography - methods; positron-emission tomography and computed tomography; Predictive Value of Tests; Prospective Studies; Radiopharmaceuticals; Sensitivity and Specificity; Tomography, X-Ray Computed; positron-emission tomography and computed tomography; diagnostic accuracy; gallbladder neoplasm; neoplasm staging; fluorodeoxiglucose F18
• ISSN: 0022-4790; 1096-9098
• DOI: 10.1002/jso.23476

Purpose To assess the value of FDG‐PET/CT in the evaluation of gallbladder carcinomas (GBC). Methods A prospective cohort of patients with suspicion of or confirmed GBC was studied with FDG‐PET/CT. Diagnostic accuracy parameters were calculated in comparison with pathology and/or the clinical course of patients. Clinical impact of PET/CT imaging was estimated. Results Forty‐nine patients were enrolled (34 malignant tumors, 15 benign lesions; 37 staging, 12 restaging). Overall diagnostic accuracy was 95.9% for the diagnosis of the primary lesion, 85.7% for lymph node involvement and 95.9% for metastatic disease. Mean SUVmax in malignant gallbladder lesions was 7.92 ± 6.25 Analysis of ROC curves showed a SUVmax cut‐off value of 3.62 for malignancy (S: 78.1%; Sp: 88.2%). Diagnostic accuracy in the restaging group reached 100%. FDG‐PET/CT changed the management of 22.4% of the population. Comments Diagnosis of malignancy or benignity of suspicious gallbladder lesions is accurately made with FDG PET/CT, allowing a precise staging of GBC due to its ability to identify unsuspected metastatic disease. SUVmax has a complementary role in addition to visual analysis. J. Surg. Oncol. 2014 109:218–224. © 2013 Wiley Periodicals, Inc.