Expression and regulation of peroxiredoxin 5 in human osteoarthritis

• Published in: FEBS letters Vol. 531; no. 2; pp. 359 - 362
• Main Authors: Wang, Min-Xia, Wei, Aiqun, Yuan, Jun, Trickett, Annette, Knoops, Bernard, Murrell, George A.C
• Format: Journal Article
• Language: English
• Published: England Elsevier B.V 06.11.2002
• Subjects: Antioxidant; Articular cartilage; Cartilage, Articular - metabolism; Cells, Cultured; Chondrocytes - drug effects; Chondrocytes - metabolism; Culture Techniques; Cytokines - pharmacology; Humans; Hydrogen Peroxide - metabolism; OA, osteoarthritis; Osteoarthritis; Osteoarthritis - genetics; Osteoarthritis - metabolism; Oxidative stress; Peroxidases - biosynthesis; Peroxidases - genetics; Peroxiredoxin 5; Peroxiredoxins; PRDX5, peroxiredoxin 5; Reactive oxygen species; RNA - biosynthesis; ROS, reactive oxygen species; Up-Regulation; Oxidative stress; Reactive oxygen species; Articular cartilage; OA, osteoarthritis; Peroxiredoxin 5; ROS, reactive oxygen species; Antioxidant; Osteoarthritis; PRDX5, peroxiredoxin 5
• ISSN: 0014-5793; 1873-3468
• DOI: 10.1016/S0014-5793(02)03511-1

Reactive oxygen species (ROS) are implicated in the pathogenesis of osteoarthritis (OA). However, little is known about the antioxidant defence system in articular cartilage. We investigated the expression and regulation of peroxiredoxin 5 (PRDX5), a newly discovered thioredoxin peroxidase, in human normal and osteoarthritic cartilage. Our results show that human cartilage constitutively expresses PRDX5. Moreover, the expression is up-regulated in OA. Inflammatory cytokines tumour necrosis factor α and interleukin 1 β contribute to this up-regulation by increasing intracellular ROS production. The present study suggests that PRDX5 may play a protective role against oxidative stress in human cartilage.