Reversible bone marrow depression by high-dose piperacillin/tazobactam

Bone marrow toxicity, mainly neutropenia, has been described as an uncommon secondary effect of most beta-lactams, and it is usually related to large cumulative doses. Although previously described for piperacillin, no cases of marrow depression caused by piperacillin/tazobactam have been reported t...

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Bibliographic Details
Published inBritish journal of haematology Vol. 95; no. 4; p. 611
Main Authors Ruiz-Irastorza, G, Barreiro, G, Aguirre, C
Format Journal Article
LanguageEnglish
Published England 01.12.1996
Subjects
Adolescent
Body Weight
Bone Marrow Diseases - chemically induced
Drug Therapy, Combination - administration & dosage
Drug Therapy, Combination - adverse effects
Female
Fever - chemically induced
Humans
Neutropenia - chemically induced
Pancytopenia - chemically induced
Penicillanic Acid - administration & dosage
Penicillanic Acid - adverse effects
Penicillanic Acid - analogs & derivatives
Piperacillin - administration & dosage
Piperacillin - adverse effects
Tazobactam
Weight Loss
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Summary:Bone marrow toxicity, mainly neutropenia, has been described as an uncommon secondary effect of most beta-lactams, and it is usually related to large cumulative doses. Although previously described for piperacillin, no cases of marrow depression caused by piperacillin/tazobactam have been reported to date. We report a case of reversible pancytopenia, with evidence of bone marrow depression, which occurred after a 17 d course of piperacillin/tazobactam. The drug was given to an underweight 18-year-old woman, at the usual dosage of 4/0.5 g three times a day. We stress the need for reducing the recommended dosage when treating underweight adult patients, and also of monitoring haematological parameters during prolonged treatments.
ISSN:0007-1048
DOI:10.1046/j.1365-2141.1996.d01-1952.x