Mast-cell responses in the development of asthma

Many cells participate in the pathogenesis of asthmatic inflammation. The mast cell is localized at the interface of the internal and external environment within the lung where it may respond to allergens and other exogenous stimuli. The activation of mast cells leads to the release of mediators tha...

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Published inJournal of allergy and clinical immunology Vol. 105; no. 2; pp. S527 - S534
Main Authors Bingham, Clifton O., Austen, K.Frank
Format Journal Article
LanguageEnglish
Published United States Mosby, Inc 01.02.2000
Subjects
Animals
asthma
Asthma - physiopathology
asthma pathogenesis
Chymases
Cytokines - physiology
Disease Progression
Eicosanoids - physiology
FcϵRI
Humans
inflammation
Mast cell
Mast Cells - metabolism
Mast Cells - physiology
mediators
Serine Endopeptidases - physiology
Tryptases
mediators
ICAM
cPLA2
asthma
BAL
IP3
ITIM
PAF
inflammation
ITAM
SCF
FcϵRI
Mast cell
asthma pathogenesis
MCT
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Summary:Many cells participate in the pathogenesis of asthmatic inflammation. The mast cell is localized at the interface of the internal and external environment within the lung where it may respond to allergens and other exogenous stimuli. The activation of mast cells leads to the release of mediators that contribute to the early phase of asthmatic inflammation. Mast-cell–derived products may also contribute to the late-phase asthmatic response. This review summarizes the developmental biologic features of the mast cell, its receptor-mediated activation, and its range of preformed, newly synthesized, and induced mediators that contribute to asthmatic inflammation. (J Allergy Clin Immunol 2000;105:S527-34.)
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ISSN:0091-6749
1097-6825
DOI:10.1016/S0091-6749(00)90056-3