Evidence based management guidelines for the detection and treatment of congenital CMV

Abstract CMV is the most common congenital infection in newborns worldwide. Congenital CMV causes sensorineural hearing loss in a significant proportion of infected newborns, while the majority of newborns are asymptomatic. In the last three years there have been significant advances in the diagnosi...

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Bibliographic Details
Published inEarly human development Vol. 87; no. 11; pp. 723 - 728
Main Authors Kadambari, S, Williams, E.J, Luck, S, Griffiths, P.D, Sharland, M
Format Journal Article Conference Proceeding
LanguageEnglish
Published Amsterdam Elsevier Ireland Ltd 01.11.2011
Elsevier
Subjects
Advanced Basic Science
Algorithms
Biological and medical sciences
Congenital
Congenital infection
Cytomegalovirus
Cytomegalovirus - isolation & purification
Cytomegalovirus - pathogenicity
Cytomegalovirus Infections - congenital
Cytomegalovirus Infections - diagnosis
Cytomegalovirus Infections - drug therapy
Cytomegalovirus Infections - urine
Cytomegalovirus Infections - virology
Diagnosis
Drug Monitoring - standards
Embryology: invertebrates and vertebrates. Teratology
Evidence-Based Medicine
Fundamental and applied biological sciences. Psychology
Ganciclovir - analogs & derivatives
Ganciclovir - pharmacology
Hearing loss
Hearing Loss, Sensorineural - congenital
Hearing Loss, Sensorineural - virology
Humans
Infant, Newborn
Neonatal and Perinatal Medicine
Neonatal Screening - methods
Neonatal Screening - standards
Neonates
Saliva - virology
Sensitivity and Specificity
Treatment
Viral Load - drug effects
Cytomegalovirus
CrUSS
Congenital
MRI
Dried blood spot
FBC
Full blood count
Central nervous system
CNS
CMV
Cranial Ultrasound
Intrauterine growth restriction
Magnetic Resonance Imaging
Liver Function Test
Treatment
DBS
IUGR
Sensorineural hearing loss
Polymerase Chain Reaction
SNHL
LFT
Diagnosis
PCR
Infection
Virus
Human
Herpesviridae
Viral disease
Betaherpesvirinae
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Summary:Abstract CMV is the most common congenital infection in newborns worldwide. Congenital CMV causes sensorineural hearing loss in a significant proportion of infected newborns, while the majority of newborns are asymptomatic. In the last three years there have been significant advances in the diagnosis and treatment of congenital CMV. We have developed practical evidence based guidelines for the management of congenital CMV.
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ISSN:0378-3782
1872-6232
DOI:10.1016/j.earlhumdev.2011.08.021