Evaluation of total oxidative status in adult attention deficit hyperactivity disorder and its diagnostic implications

• Published in: Journal of psychiatric research Vol. 46; no. 4; pp. 451 - 455
• Main Authors: Selek, Salih, Bulut, Mahmut, Ocak, Ali Rza, Kalenderoğlu, Aysun, Savaş, Haluk A
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 01.04.2012; Elsevier
• Subjects: Adolescent; Adult; Adult attention deficit hyperactivity disorder; Analysis of Variance; Antioxidants - metabolism; Attention Deficit Disorder with Hyperactivity - blood; Attention Deficit Disorder with Hyperactivity - diagnosis; Attention Deficit Disorder with Hyperactivity - physiopathology; Attention deficit disorders. Hyperactivity; Attention deficit hyperactivity disorder; Biochemistry; Biological and medical sciences; Child clinical studies; Comorbidity; Diagnosis; Environmental aspects; Female; Humans; Hydrogen Peroxide - blood; Male; Medical sciences; Middle Aged; Neurochemicals; Oxidants - blood; Oxidative stress; Oxidative Stress - physiology; Oxidative stress index; Predictive Value of Tests; Psychiatric disorders; Psychiatric Status Rating Scales; Psychiatry; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; ROC Curve; Spectrophotometry; Total antioxidative status; Total oxidative status; Young Adult; Total antioxidative status; Total oxidative status; Oxidative stress; Adult attention deficit hyperactivity disorder; Diagnosis; Oxidative stress index; Human; Evaluation; Adult; Attention disorder with hyperactivity
• ISSN: 0022-3956; 1879-1379
• DOI: 10.1016/j.jpsychires.2011.12.007

Abstract Adult Attention Deficit Hyperactivity Disorder (A-ADHD) is one of the psychiatric disorders which awareness is growing. The exact causes of A-ADHD are still unknown. In addition to neurochemical and neuroanatomic disorders, genetic and environmental factors are discussed in its etiology. In our study, we aimed to evaluate the oxidative status of A-ADHD patients and investigate whether oxidative metabolites can be used as diagnostic tools or not in A-ADHD. Blood samples were taken from enrolled 50 A-ADHD patients and 31 controls in appropriate way and Total Antioxidative Status (TAS), Total Oxidative Status (TOS), and Oxidative Stress Index (OSI) were studied in Harran University Biochemistry Labs. Results were compared between groups and ROC curve was drawn in order to evaluate diagnostic performances. Patients' TAS, TOS and OSI were significantly higher than controls. There was not a significant difference between comorbid cases and only A-ADHD patients in terms of measured values. A-ADHD can be predicted for TOS over 9.8575 μmol H2 O2 Eqv./L level with 86% positive predictive value and %100 negative predictive value. In A-ADHD, oxidative balance is impaired. High antioxidant levels may be compensatory against the oxidant increase. Oxidative parameters may be used in A-ADHD diagnosis.