Colonoscopy screening for individuals aged 40-49 years with a family history of stomach cancer in Korea

• Published in: International journal of colorectal disease Vol. 25; no. 4; pp. 443 - 447
• Main Authors: Choi, Yong Sung, Suh, Jung Pil, Lee, Doo Seok, Youk, Eui Gon, Lee, In Taek, Lee, Suk Hee, Kim, Do Sun, Lee, Doo Han
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Berlin/Heidelberg : Springer-Verlag 01.04.2010; Springer-Verlag; Springer; Springer Nature B.V
• Subjects: Adenoma - epidemiology; Adult; Biological and medical sciences; Cancer; Colon cancer; Colonic Neoplasms - epidemiology; Colonoscopy; Colonoscopy - statistics & numerical data; Diagnosis; Digestive system. Abdomen; Endoscopy; Family Health; Female; Gastroenterology; Gastroenterology. Liver. Pancreas. Abdomen; Hepatology; Humans; Internal Medicine; Investigative techniques, diagnostic techniques (general aspects); Korea - epidemiology; Male; Mass Screening - methods; Mass Screening - statistics & numerical data; Medical sciences; Medicine; Medicine & Public Health; Middle Aged; Original Article; Prevalence; Proctology; Risk Assessment; Risk Factors; Stomach cancer; Stomach Neoplasms - epidemiology; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus; Surgery; Tumors; Asia; Korea; Family history of stomach cancer; Screening; Adenoma; Human; Family study; Malignant tumor; Medical screening; Stomach cancer; Colonoscopy; Gastroenterology; Digestive diseases; Benign neoplasm; Endoscopy; Cancer; Gastric disease
• ISSN: 0179-1958; 1432-1262
• DOI: 10.1007/s00384-009-0855-3

Background For asymptomatic individuals aged 40-49 years, screening for colorectal cancer is recommended only if individuals are at an increased risk. A family history of colon cancer (FHCRC) is considered to increase risk, however, whether family history of stomach cancer (FHSC) increases the risk of adenoma is not well known. We aimed to see whether FHSC increases the risk in asymptomatic individuals aged 40-49 years in Korea. Methods Among asymptomatic individual aged 40-49 years who underwent colonoscopy screening, risk of adenoma was assessed according to FHCRC or FHSC. Results Of 3,160 individuals, male comprised 1,602 individuals (50.7%). FHCRC and FHSC was noticed in 163 (5.2%) and 227 (7.0%) individuals, respectively. Prevalence of adenoma was 31.9 %, 28.8%, and 22.3% for individuals with FHCRC, individuals with FHSC, and individuals without family history of cancer, respectively. FHSC was an independent risk factor for adenoma (odds ratio, 1.38; 95% confidence interval, 1.02-1.87, P = 0.039) in asymptomatic individuals aged 40-49 years. Compared with individuals with FHCRC, individuals with FHSC showed no difference in risk for adenoma (P = 0.347). Conclusions As with individuals with FHCRC, individuals with FHSC might need to be considered as an individual with increased risk for adenoma. Therefore, earlier screening might be needed for asymptomatic individuals aged 40-49 years with FHSC in Korea.