Antidepressant-like effects of Chaihu-Shugan-San via SAPK/JNK signal transduction in rat models of depression

Chaihu-Shugan-San (CHSGS), a traditional Chinese medicinal herbal formula, registered in Jingyue Quanshu, has been indicated that oral administration of the extract from it can remit depressive disorder. C-Jun amino-terminal kinase (JNK/SAPK) signal transduction plays a key role in the apoptosis of...

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Published inPharmacognosy Magazine Vol. 10; no. 39; pp. 271 - 277
Main Authors Li, Yun-Hui, Zhang, Chun-Hu, Qiu, Juan, Wang, Su-E, Hu, Sui-Yu, Huang, Xi, Xie, Ying, Wang, Yang, Cheng, Tian-Li
Format Journal Article
LanguageEnglish
Published India Medknow Publications and Media Pvt. Ltd 01.07.2014
Sage Publications Ltd
Medknow Publications & Media Pvt Ltd
Subjects
Antidepressants
Behavior
Cellular signal transduction
Chinese medicine
Depression, Mental
Drug dosages
Drug therapy
Health aspects
Hospitals
Kinases
Original
Polyclonal antibodies
Proteins
Rodents
Studies
Transcription factors
Antidepressant
Chaihu-Shugan-San
C-Jun amino-terminal kinase
fluoxetine
open field test
signal transduction
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Summary:Chaihu-Shugan-San (CHSGS), a traditional Chinese medicinal herbal formula, registered in Jingyue Quanshu, has been indicated that oral administration of the extract from it can remit depressive disorder. C-Jun amino-terminal kinase (JNK/SAPK) signal transduction plays a key role in the apoptosis of nerve cells, be reported closely correlated with depression. This study was designed to investigate CHSGS antidepressant-like effects in rat models of depression and probe its possible mechanism. The classical experimental depression model chronic mild unpredictable stress (CMUS) was used to evaluate the antidepressant-like effects of CHSGS. The extracts were administered orally for 14 days, while the parallel positive control was given at the same time using fluoxetine hydrochloride. The expressions of JNK in the hippocampus were detected by real-time fluorescent quantitation PCR and Western blot assay. Intragastric administration of CHSGS for 14 days caused a significant improvement of weight and locomotor activity in the open-field test. In addition, CHSGS treatment inhibited the expressions of JNK in the hippocampus tissue in CMUS rats. CHSGS could obviously improve the depressive state of the model rats and its mechanism may be correlated with regulating the expressions of JNK in the hippocampus.
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ISSN:0973-1296
0976-4062
DOI:10.4103/0973-1296.137367