Physical Mapping of the Retinoblastoma Interacting Zinc Finger Gene RIZ to D1S228 on Chromosome 1p36

• Published in: Genomics (San Diego, Calif.) Vol. 34; no. 1; pp. 119 - 121
• Main Authors: Buyse, Inge M., Takahashi, Ei-ichi, Huang, Shi
• Format: Journal Article
• Language: English
• Published: San Diego, CA Elsevier Inc 15.05.1996; Elsevier
• Subjects: Base Sequence; Biological and medical sciences; Chromosome Mapping; Chromosomes, Artificial, Yeast; Chromosomes, Human, Pair 1; Classical genetics, quantitative genetics, hybrids; DNA-Binding Proteins; Fundamental and applied biological sciences. Psychology; Genetic Markers; Genetics of eukaryotes. Biological and molecular evolution; Histone-Lysine N-Methyltransferase; Human; Humans; In Situ Hybridization, Fluorescence; Molecular Sequence Data; Nuclear Proteins - genetics; Transcription Factors; Genetic mapping; Human; Binding protein; Gene; Genetic marker; Zinc finger structure; Chromosome A1; Retinoblastoma protein
• ISSN: 0888-7543; 1089-8646
• DOI: 10.1006/geno.1996.0249

The retinoblastoma interacting zinc finger gene RIZ is a member of the recently discovered PR domain family that includes the MDS1–EVI1 breakpoint gene involved in human leukemia. To help understand the role of RIZ in human diseases, we have determined the cytogenetic and physical localizations of the RIZ gene. Using fluorescencein situhybridization, we determined that RIZ maps to 1p36. On the physical map, RIZ is adjacent to the polymorphic marker D1S228. We suggest that the RIZ gene may be a candidate target of 1p36 alterations that commonly occur in neuroendocrine, breast, liver, colon, and lymphoid tumors.