Neurocysticercosis Among Zambian Children and Adolescents With Human Immunodeficiency Virus: A Geographic Information Systems Approach

• Published in: Pediatric neurology Vol. 102; pp. 36 - 43
• Main Authors: Buda, Alexandra, Dean, Owen, Adams, Heather R., Mwanza-Kabaghe, Sylvia, Potchen, Michael J., Mbewe, Esau G., Kabundula, Pelekelo P., Moghaddam, Sarah Mohajeri, Mweemba, Milimo, Matoka, Beauty, Mathews, Manoj M., Birbeck, Gretchen L., Bearden, David R.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.01.2020
• Subjects: Adolescent; Africa; Child; Comorbidity; Female; Geographic Information Systems; HIV; HIV Infections - diagnostic imaging; HIV Infections - epidemiology; Humans; Longitudinal Studies; Magnetic Resonance Imaging; Male; MRI; Neurocysticercosis; Neurocysticercosis - diagnostic imaging; Neurocysticercosis - epidemiology; Zambia; Zambia - epidemiology; Zambia; Neurocysticercosis; Zambia; HIV; MRI; Africa
• ISSN: 0887-8994; 1873-5150
• DOI: 10.1016/j.pediatrneurol.2019.07.017

Neurocysticercosis is the most common parasitic infection of the brain and a leading cause of epilepsy in resource-limited settings. Although neurocysticercosis and human immunodeficiency virus coinfections have commonly been reported, there are few data on how they interact. As part of an observational study of human immunodeficiency virus and cognition in Lusaka, Zambia, we identified a cluster of subjects with neurocysticercosis. We hypothesized that the neighborhood of residence may be an important factor driving clustering of neurocysticercosis and used a geographic information systems approach to investigate this association. A total of 34 subjects with human immunodeficiency virus and 13 subjects without human immunodeficiency virus (aged eight to 17 years) enrolled in the HIV-Associated Neurocognitive Disorders in Zambia study, had magnetic resonance imaging of the brain performed, and were evaluated for neurocysticercosis. Quantitative geographic information systems was utilized to investigate the relationship between neighborhood of residence, HIV, and neurocysticercosis. Three of 34 subjects with human immunodeficiency virus (8.82%) and one of 13 controls were found to have neurocysticercosis. Geographic cluster analysis demonstrated that all subjects with neurocysticercosis were clustered in two adjacent neighborhoods (Chawama and Kanyama) with lower rates of piped water (Chawama: 22.8%, Kanyama: 26.7%) and flush toilets (Chawama: 14.0%, Kanyama: 14.0%) than the surrounding neighborhoods. We describe a cluster of patients with both neurocysticercosis and human immunodeficiency virus in Lusaka. Cases of neurocysticercosis clustered in neighborhoods with low rates of piped water and limited access to flush toilets. Geographic information systems may be a useful approach for studying the relationship between human immunodeficiency virus and neurocysticercosis. Larger studies are necessary to further investigate this association.