Body composition of adults with a history of severe acute malnutrition during childhood using the deuterium dilution method in eastern DR Congo: the Lwiro Cohort Study

• Published in: The American journal of clinical nutrition Vol. 114; no. 6; pp. 2052 - 2059
• Main Authors: Mwene-Batu, Pacifique, Wells, Jonathan, Maheshe, Ghislain, Hermans, Michel P, Kalumuna, Esther, Ngaboyeka, Gaylord, Chimanuka, Christine, Owino, Victor O, Macq, Jean, Lukula, Melissa, Dramaix, Michelle, Donnen, Philippe, Bisimwa, Ghislain
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.12.2021; Oxford University Press; American Society for Clinical Nutrition, Inc
• Subjects: acute malnutrition; Adipose Tissue; Adult; Adults; Body Composition; Body fat; Body height; Body Mass Index; Child; Childhood; Children; Cohort analysis; Cohort Studies; Democratic Republic of the Congo; Deuterium; deuterium dilution method; Dilution; DR Congo; Evaluation; Exposure; Fat-free body mass; Female; Females; Humans; long-term effect; Male; Males; Malnutrition; Observational studies; Original Research Communications; Rehabilitation; Severe Acute Malnutrition; Sex; Young Adult; Young adults; Democratic Republic of the Congo; BC; FMI; FM; TBW; CMAM; FFM; NCD; body composition; CHW; RUTF; DRC; deuterium dilution method; DR Congo; IAEA; LMIC; long-term effect; acute malnutrition; FFMI; SAM
• ISSN: 0002-9165; 1938-3207; 1938-3207
• DOI: 10.1093/ajcn/nqab293

Few studies have evaluated the body composition (BC) of adults who suffered from severe acute malnutrition (SAM) during childhood, a population at risk of long-term noncommunicable diseases. We performed an observational cohort study to evaluate BC in a group of young adults aged 11–30 y after nutritional rehabilitation for SAM, in the Democratic Republic of the Congo (DRC). We evaluated 151 adults in eastern DRC who were treated for SAM during childhood between 1988 and 2007. They were compared with 120 aged- and sex-matched control adults living in the same community who had not been exposed to malnutrition as children. The main variables of interest were the different compartments of adult BC (fat-free mass [FFM], fat mass [FM], and 2 indices of height-normalized BC: FFM index [FFMI] and FM index [FMI]) measured by deuterium dilution. The mean age in both groups was 23 y, and females represented 49% and 56% of the exposed and nonexposed groups, respectively. SAM-exposed males had lower mean ± SD weight (53.6 ± 6.4 compared with 56.4 ± 7.9 kg, P = 0.029) and lower height (159.9 ± 6.6 compared with 163.6 ± 6.7 cm, P = 0.003) compared to unexposed males. SAM-exposed subjects had less FFM (–1.56 kg [–2.93, –0.20]; P = 0.024) but this observation was more marked in males (45.4 ± 5.4 compared with 48.2 ± 6.9 kg, P = 0.01) than in females. No differences in FM were noted between SAM-exposed and unexposed subjects. Adjusting for height, FFMI and FMI showed no difference between SAM-exposed and unexposed in either sex. SAM during childhood is associated with reduced FFM in adulthood which is probably due to a shorter height.