Clearing the Brain's Amyloid Cobwebs

Elevated cerebral levels of amyloid β-protein occur universally in Alzheimer's disease, yet only a few patients show evidence of increased Aβ production. Therefore, defects in proteases that degrade Aβ could underlie some or many cases of familial and sporadic AD. This previously neglected topi...

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Bibliographic Details
Published inNeuron Vol. 32; no. 2; pp. 177 - 180
Main Author Selkoe, Dennis J.
Format Book Review Journal Article
LanguageEnglish
Published United States Elsevier Inc 25.10.2001
Subjects
Alzheimer Disease - enzymology
Alzheimer Disease - genetics
Amyloid beta-Peptides - metabolism
Animals
Brain - enzymology
Endopeptidases - genetics
Endopeptidases - metabolism
Humans
Insulysin - metabolism
Mutation
Neprilysin - metabolism
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Summary:Elevated cerebral levels of amyloid β-protein occur universally in Alzheimer's disease, yet only a few patients show evidence of increased Aβ production. Therefore, defects in proteases that degrade Aβ could underlie some or many cases of familial and sporadic AD. This previously neglected topic has begun receiving serious attention. Understanding how proteolysis regulates Aβ levels in the cerebral cortex has implications for both the pathogenesis and the treatment of this protean disorder.
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ISSN:0896-6273
1097-4199
DOI:10.1016/S0896-6273(01)00475-5