Possibility of Müller Cell Dysfunction as the Pathogenesis of Paclitaxel Maculopathy

Cystoid macular edema (CME) without leakage is an adverse complication of paclitaxel administration in patients with cancer. However, the mechanism of non-leaking CME has been unclear. The authors report the case of a 66-year-old man who developed non-leaking CME during treatment with paclitaxel for...

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Bibliographic Details
Published inOphthalmic surgery, lasers & imaging Vol. 47; no. 1; pp. 81 - 84
Main Authors Nakao, Shintaro, Ikeda, Yasuhiro, Emi, Yasunori, Ishibashi, Tatsuro
Format Journal Article
LanguageEnglish
Published United States SLACK INCORPORATED 01.01.2016
Subjects
Aged
Antineoplastic Agents, Phytogenic - adverse effects
Camptothecin - analogs & derivatives
Camptothecin - therapeutic use
Chemotherapy
Drug Substitution
Electroretinography
Ependymoglial Cells - pathology
Eye diseases
Fluorescein Angiography
Gastric cancer
Humans
Macular Edema - chemically induced
Macular Edema - diagnosis
Male
Paclitaxel - adverse effects
Pathogenesis
Side effects
Stomach Neoplasms - drug therapy
Tomography, Optical Coherence
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Summary:Cystoid macular edema (CME) without leakage is an adverse complication of paclitaxel administration in patients with cancer. However, the mechanism of non-leaking CME has been unclear. The authors report the case of a 66-year-old man who developed non-leaking CME during treatment with paclitaxel for gastric cancer. This case report suggests possible pathogenesis of paclitaxel-induced CME without evidence of leakage at angiography from the data of electroretinogram. [[ Ophthalmic Surg Imaging Lasers Retina . 2016;47:81–84.]
Bibliography:ObjectType-Case Study-2
SourceType-Scholarly Journals-1
ObjectType-Feature-4
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ObjectType-Report-1
ObjectType-Article-3
ISSN:2325-8160
2325-8179
DOI:10.3928/23258160-20151214-14