Long-term exposure to low levels of formaldehyde increases the number of tyrosine hydroxylase-immunopositive periglomerular cells in mouse main olfactory bulb

• Published in: Brain research Vol. 1007; no. 1; pp. 192 - 197
• Main Authors: Hayashi, Hiroshi, Kunugita, Naoki, Arashidani, Keiichi, Fujimaki, Hidekazu, Ichikawa, Masumi
• Format: Journal Article
• Language: English
• Published: London Elsevier B.V 08.05.2004; Amsterdam Elsevier; New York, NY
• Subjects: Animals; Biological and medical sciences; Cell Count - methods; Disinfectants - pharmacology; Dopamine; Dose-Response Relationship, Drug; Female; Formaldehyde - pharmacology; Fundamental and applied biological sciences. Psychology; Immunohistochemistry - methods; Mice; Mice, Inbred Strains; Multiple chemical sensitivity; Neurons - drug effects; Neurons - enzymology; Olfaction; Olfactory Bulb - cytology; Olfactory system and olfaction. Gustatory system and gustation; Periglomerular cell; Time; Time Factors; Tyrosine 3-Monooxygenase - metabolism; Vertebrates: nervous system and sense organs; Sensory systems; Periglomerular cell; Dopamine; Multiple chemical sensitivity; Olfaction; Enzyme; Rodentia; Central nervous system; Tyrosine 3-monooxygenase; Formaldehyde; Encephalon; Vertebrata; Mammalia; Olfactory pathway; Mouse; Olfactory bulb; Oxidoreductases
• ISSN: 0006-8993; 1872-6240
• DOI: 10.1016/j.brainres.2003.12.052

Multiple chemical sensitivity (MCS) in response to a long-term low-level chemical exposure is as yet an unclarified disorder. To determine the role of olfactory function in the induction of MCS, immunocytochemical analysis of the main olfactory bulb (MOB) was performed after exposure of mice to low levels of formaldehyde. A long-term exposure resulted in an increase in the number of tyrosine hydroxylase-immunopositive periglomerular cells and may affect the neuronal function of the MOB.